The American Society for Transplantation and Cellular Therapy (ASTCT) updated its guidelines about BMT to include CAR T-cell therapy.
BMT has been used for more than 50 years
Because BMT can have serious side effects, it is not used for everyone. However, newer treatments that are given before BMT, called reduced-intensity conditioning, cause fewer side effects than older treatments.
So doctors now suggest BMT for more people than before. Even older adults can get life-saving BMT, as long as they are healthy enough.
CAR T-cell therapy uses modified blood cells to kill cancer cells
In the U.S. as of January 2021, CAR T-cells are used only after regular treatments fail to control these cancers:
- mantle cell lymphoma,
- diffuse large B-cell lymphoma,
- and acute lymphoblastic leukemia (ALL).
Scientists are working to create CAR T-cell therapies for more diseases.