In this study, 758 adults with multiple myeloma were treated at 54 medical centers around the U.S. from 2010 to 2017. The people were randomly divided into 3 treatment groups:
- 1 auto transplant
- 2 auto transplants (also called tandem transplants)
- 1 auto transplant plus extra medicines, called RVD
Then, everyone took a medicine called lenalidomide for maintenance therapy.
The treatments worked equally well, scientists said. At 3 years after transplant:
- The myeloma was not worse for more than half the people
- About 80% (8 out of 10 people) were alive
The chemo to prepare for transplant has side effects. And the extra medicines, called RVD, have side effects, too. So, it is helpful to know that just 1 transplant works as well as 2 transplants or 1 transplant plus RVD. With only 1 transplant, people might have side effects less often than if they had many treatments.