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A drug, PTX-100, to treat cutaneous T-cell lymphoma (CTCL) that has come back (relapsed) or not gotten better with treatment (refractory)

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18 and older

Phase 2

6 Locations

NCT06854653

Clinical Trial Goal


To find out if PTX-100 is safe and works well to treat CTCL that has relapsed or is refractory

You may be able to join this trial if you:


  • Are 18 years old or older
  • Have CTCL that has relapsed or is refractory
  • Do not have lymphoma in your brain or spinal cord
  • Have not had an allogeneic (cells from a donor) or autologous (your own cells) blood or marrow transplant (BMT) 
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


PTX-100 is a peptidomimetic inhibitor that targets geranylgeranyltransferase type 1 (GGTase-I) on certain cells. 

You’ll get treatment in cycles that last 2 to 3 weeks. In each cycle, you'll get: 
  • PTX-100– Given as intravenous (IV) infusions 1 time each day for 5 days

You may continue treatment for up to 1.5 years. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 1.5 years.

The Food and Drug Administration (FDA) has not yet approved PTX-100. 

Contacts


Upaly Bahadure, +61 3 9692 7222, upaly@ptxtherapeutics.com

David Wong, david.wong@ptxtherapeutics.com

Locations

City of Hope Comprehensive Cancer CenteRECRUITING

Duarte, California
Linda Devine, +1 800-826-4673

University of California IrvineRECRUITING

Irvine, California
714-456-7890

Yale Cancer CenterNOT_YET_RECRUITING

New Haven, Connecticut
203-785-4095

Dana-Farber Cancer InstituteRECRUITING

Boston, Massachusetts
+1 877-442-3324

Rochester Skin Lymphoma Medical Group. PLLCRECRUITING

Rochester, New York
Brian Poligone, MD, PhD, 585-364-1188, bpoligone@roclymphoma.com

Virginia Commonwealth University Massey Comprehensive Cancer CenteRECRUITING

Richmond, Virginia
804-828-7999

ClinicalTrials.gov record


NCT06854653. First posted on Mar 3

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