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A drug, DSP-5336, to treat acute leukemia that has come back (relapsed) or has not gotten better with treatment (refractory)

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18 and older

Phase 1, Phase 2

29 Locations

NCT04988555

Clinical Trial Goal


To find out:
  • The highest dose of DSP-5336 that’s safe to give
  • If DSP-5336 is safe and works well to treat acute leukemia that has relapsed or is refractory

You may be able to join this trial if you:


  • Are 18 years old or older
  • Have one of the following:
    • Acute lymphoblastic leukemia (ALL)
    • Acute myeloid leukemia (AML)
  • Do not have acute promyelocytic leukemia
  • Do not have untreated lymphoma in your brain or spinal cord
  • Have not had a blood or marrow transplant (BMT) or cell therapy in the last 2 months. 
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


DSP-5336 is a small molecule inhibitor that blocks the menin-MLL interaction in certain cells. 

You’ll get:
  • DSP-5336 – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been

You may continue treatment for as long as the clinical trial doctors think it’s best for your health. You'll have biopsies to see how well the treatment is working.

The Food and Drug Administration (FDA) has not yet approved DSP-5336.

Contacts


Matt Hitron, MD, 508-481-6700, matthew.hitron@us.sumitomo-pharma.com

Tomoko Kuwabara, tomoko.kuwabara@us.sumitomo-pharma.com

Locations

Hoag Family Cancer CenterNOT_YET_RECRUITING

Newport Beach, California
Benjamin Goldenson, MD, benjamin.goldenson@hoag.org

Colorado Blood Cancer InstituteRECRUITING

Denver, Colorado
Alireza Eghtedar, MD, 720-754-4800

University of MiamiRECRUITING

Miami, Florida
Justin Watts, MD, 305-243-8986, jxw401@miami.edu

NorthwesternNOT_YET_RECRUITING

Chicago, Illinois
Yasmin Abaza, MD, yasmin.abaza@nm.org

University of MarylandNOT_YET_RECRUITING

Baltimore, Maryland
Maria Baer, MD, mbaer@umm.edu

Johns Hopkins Main CenterRECRUITING

Baltimore, Maryland
Mark Levis, MD, levisma@jhmi.edu

Sibley Memorial HospitalRECRUITING

Baltimore, Maryland
Mark Levis, MD, levisma@jhmi.edu

Tufts UniversityNOT_YET_RECRUITING

Boston, Massachusetts
Andreas Klein, MD, akein2@tuftsmedicalcenter.org

Massachusetts General HospitalRECRUITING

Boston, Massachusetts
Andrew Brunner, MD, abrunner@mgb.org

Atlantic HealthRECRUITING

Morristown, New Jersey
Mohamad Cherry, MD, mohamad.cherry@atlantichealth.org

Rutgers Cancer Institute of New JerseyRECRUITING

New Brunswick, New Jersey
Neil Palmisiano, MD, np938@cinj.rutgers.edu

Columbia UniversityRECRUITING

New York, New York
Joseph Jurcic, MD, jgj2110@cumc.columbia.edu

Mount Sinai HospitalRECRUITING

New York, New York
Douglas Tremblay, MD, douglas.tremblay@mssm.edu

Roswell Park Comprehensive Cancer CenterRECRUITING

Buffalo, New York
Eunice Wang, MD, Eunice.Wang@RoswellPark.org

Atrium Wake Forest Baptist Medical CenterRECRUITING

Winston-Salem, North Carolina
Timothy Pardee, MD, tspardee@wakehealth.edu

Duke UniversityRECRUITING

Durham, North Carolina
Harry Erba, MD, 919-684-8964, harry.erba@duke.edu

UNC HospitalRECRUITING

Chapel Hill, North Carolina
Joshua Zeidner, MD, joshua_zeidner@med.unc.edu

The Ohio State University Comprehensive Cancer CenterRECRUITING

Columbus, Ohio
Kristen Browning, MD, Kristen.Browning@osumc.edu

Oncology Associates of OregonRECRUITING

Eugene, Oregon
Luke Fletcher, MD, luke.fletcher@usoncology.com

Allegheny Health NetworkRECRUITING

Pittsburgh, Pennsylvania
Salman Fazal, MD, salman.fazal@ahn.org

Sidney Kimmel Comprehensive Cancer CenterRECRUITING

Philadelphia, Pennsylvania
Gina Keiffer, MD, gina.keiffer@jefferson.edu

Medical University of South CarolinaRECRUITING

Charleston, South Carolina
Praneeth Baratam, MD, baratamp@musc.edu

TriStar Centennial Medical CenterRECRUITING

Nashville, Tennessee
Stephen Strickland, MD, Stephen.Strickland@hcahealthcare.com

MDACCRECRUITING

Houston, Texas
Naval Daver, MD, 7137944392, NDaver@mdanderson.org

Intermountain HealthcareNOT_YET_RECRUITING

Salt Lake City, Utah
Bradley Hunter, MD, brad.hunter@imail.org

Huntsman Cancer InstituteRECRUITING

Salt Lake City, Utah
Paul Shami, MD, paul.shami@utah.edu

University of VirginiaRECRUITING

Charlottesville, Virginia
Michael Keng, MD, mk2pv@uvahealth.org

Virginia Cancer SpecialistsRECRUITING

Fairfax, Virginia
Mitul Gandhi, MD, mitul.gandhi@usoncology.com

Virginia Oncology AssociatesRECRUITING

Norfolk, Virginia
Celeste Bremer, MD, celesteann.bremer@usoncology.com

ClinicalTrials.gov record


NCT04988555. First posted on 8/3/21

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