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A drug, ABBV-319, to treat chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma that has come back (relapsed) or has not gotten better with treatment (refractory)

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18 and older

Phase 1

8 Locations

NCT05512390

Clinical Trial Goal


To find out:
  • The highest dose of ABBV-319 that’s safe to give
  • If ABBV-319 is safe and works well to treat CLL, DLBCL and follicular lymphoma that has relapsed or is refractory

You may be able to join this trial if you:


  • Are 18 years old or older
  • Have one of the following that has relapsed or is refractory:
    • CLL
    • DLBCL
    • Follicular lymphoma
  • Do not have lymphoma in your brain or spinal cord
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


ABBV-319 is a glucocorticoid that targets CD19 on certain cells. 
 
You’ll get treatment in cycles that last 3 weeks. In each cycle, you'll get: 
  • ABBV-319 – Given as intravenous (IV) infusions. The dose you'll get depends on when you start the trial and how safe it has been

You may continue treatment for as long as the clinical trial doctors think it’s best for your health. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 2.5 years.

The Food and Drug Administration (FDA) has not yet approved ABBV-319. 

Contacts


ABBVIE CALL CENTER, 844-663-3742, abbvieclinicaltrials@abbvie.com

Locations

University of Arizona Cancer Center - Tucson /ID# 247752RECRUITING

Tucson, Arizona

Sylvester Comprehensive Cancer Center - University of Miami /ID# 247232COMPLETED

Miami, Florida

Allina Health System /ID# 251782RECRUITING

Minneapolis, Minnesota

University of Nebraska Medical Center /ID# 246715RECRUITING

Omaha, Nebraska

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 249246RECRUITING

New York, New York

Novant Health Presbyterian Medical Center /ID# 246719RECRUITING

Charlotte, North Carolina

Baylor Sammons Cancer Center /ID# 247715RECRUITING

Dallas, Texas

University of Texas Health San Antonio MD Anderson Cancer Center /ID# 256234RECRUITING

San Antonio, Texas

ClinicalTrials.gov record


NCT05512390. First posted on 8/23/22

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