Clinical Trial Goal
To find out:
- The highest dose of ethinyl estradiol/levonorgestrel that’s safe to give with venetoclax
- If venetoclax changes the effectiveness of an oral contraceptive (ethinyl estradiol/levonogestrel)
You may be able to join this trial if you:
- Are 18 years or older
- Were assigned female at birth
- Have NHL that has relapsed or is refractory. Some examples include:
- Diffuse large B-cell lymphoma (DLBCL)
- Follicular lymphoma
- Lymphoplasmacytic lymphoma (LPL)
- Mantle cell lymphoma (MCL)
- Marginal zone lymphoma (MZL)
- T-cell prolymphocytic lymphoma
- Waldenstrom's macroglobulinemia
- Have not had an autologous (your own cells) or allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Ethinyl estradiol/levonorgestrel is an oral contraceptive containing progestin and estrogen used to prevent pregnancy.
Venetoclax is a small molecule inhibitor that blocks BCL2 in certain cells.
You’ll get:
Venetoclax is a small molecule inhibitor that blocks BCL2 in certain cells.
You’ll get:
- Ethinyl estradiol/levonorgestrel – A pill that you take by mouth 2 times
- Venetoclax – A pill that you take by mouth 1 time each day
You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 2 months.
The Food and Drug Administration (FDA) has approved all of the drugs used in this trial.
Locations
Duplicate_Henry Ford Health System /ID# 209090COMPLETED
Detroit, Michigan
Dartmouth-Hitchcock Medical Center /ID# 169097COMPLETED
Lebanon, New Hampshire
Gabrail Cancer Center Research /ID# 207039COMPLETED
Canton, Ohio
Sponsors
lead: AbbVie
