Clinical Trial Goal
To find out:
- The highest dose of BMS-986470 that's safe to give
- If BMS-986470 is safe and works well to treat SCD
You may be able to join this trial if you:
- Are 18 years old or older
- Have SCD (HbSS or HbSβ0)
- Have had 1 of the following:
- 4 or more pain crises in the past year
- 2 or more pain crises in the past 6 months
- Have not had a pain crisis in the last month that required hospitalization for longer than 1 day
- Have not had more than 6 pain crises in the last year that required hospitalization for longer than 1 day
- Have not had acute chest syndrome (ACS) in the past 6 months
- Have not gotten a blood transfusion in the last month
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
BMS-986470 is a small molecule cereblon E3 ligase modulator (CELMoD) that doctors think will increase fetal hemoglobin (HbF).
Everyone in this trial will get standard drugs to treat pain.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
- Group 1 – BMS-986470
- Group 2 – BMS-986470 plus placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You’ll get:
- BMS-986470 – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
You may continue treatment for as long as the clinical trial doctors think it’s best for your health. The clinical trial doctors will check your health for up to about 5 months.
The Food and Drug Administration (FDA) not yet approved BMS-986470.
The Food and Drug Administration (FDA) not yet approved BMS-986470.
Contacts
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, 855-907-3286, Clinical.Trials@bms.com
First line of the email MUST contain the NCT# and Site #.
Locations
Sponsors
lead: Bristol-Myers Squibb
