Welcome to the Jason Carter Clinical Trials Website
Our website helps patients find clinical trials. We currently offer patient-friendly descriptions of leukemia and lymphoma trials. Early in 2018, we will be:
Adding patient-friendly trial descriptions for other blood cancers and disorders
Making improvements to the search tool
Expanding our educational resources
Didn't find a trial or need help? Contact our clinical trial specialist at 888-814-8610 or contact@ctsearchsupport.org.
The highest dose of ziftomenib that’s safe to give with other standard chemo
If the combination of ziftomenib and other standard chemo is safe and works well to treat AML
You may be able to join this trial if you:
Are 18 years old or older
Have AML
Have leukemia cells with NPM1 mutation or KMT2A rearrangement. Your doctor can tell you this
Do not have acute promyelocytic leukemia or chronic myelomonocytic leukemia
Do not have untreated leukemia cells in your brain or spinal cord
Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Azacitidine is a drug that blocks the growth of cancer cells. Cytarabine and daunorubicin are chemotherapy (chemo) drugs that block the growth of cancer cells. Venetoclax is a small molecule inhibitor that blocks BCL2 in certain cells. Ziftomenib is a small molecule inhibitor that blocks KMT2A in certain cells.
You will get:
Ziftomenib – A pill you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
The other drugs you get will depend on whether:
Your leukemia cells have NPM1 mutation or KMT2A rearrangement
Your AML is newly diagnosed or it has come back (relapsed) or not gotten better with treatment (refractory)
You'll also get 1 or 2 of these drugs:
Azacitidine – Given as a shot under your skin or an intravenous (IV infusion).
Cytarabine – Given as an IV infusion.
Daunorubicin – Given as an IV infusion.
Venetoclax – A pill you take by mouth.
You may continue treatment for as long as the clinical trial doctors think it’s best for your health. You'll have biopsies and/or scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 1 year after you stop treatment.
The Food and Drug Administration (FDA) has approved all of the drugs used in this trial. Using them in this way to treat AML is new and unproven.
