Clinical Trial Goal
To find out:
- The highest dose of GSK4172239D that’s safe to give
- If GSK4172239D is safe and works well to treat SCD
You may be able to join this trial if you:
- Are 18 – 50 years old
- Have SCD
- Have tried at least one other approved treatment for SCD. Your doctor can tell you this
- Are not taking medicine to increase fetal hemoglobin. Your doctor can tell you this
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
GSK4172239D is a drug that targets DNMT1 in certain cells.
Everyone in this trial will get standard drugs to treat pain.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Everyone in this trial will get standard drugs to treat pain.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
- Group 1 – GSK4172239D
- Group 2 – Placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You’ll get:
- GSK4172239D – Group 1 only - A pill that you take by mouth 1 time. The dose you'll get depends on when you start the trial and how safe it has been
- Placebo – Group 2 only - A pill that you take by mouth 1 time
Some people will be asked to take another dose of either GSK4172239D or placebo and eat high calorie and high fat foods for a short time.
The Food and Drug Administration (FDA) has not yet approved GSK4172239D.
Contacts
US GSK Clinical Trials Call Center, 877-379-3718, GSKClinicalSupportHD@gsk.com
EU GSK Clinical Trials Call Center, +44 (0) 20 89904466, GSKClinicalSupportHD@gsk.com
Locations
Sponsors
lead: GlaxoSmithKline
