Clinical Trial Goal
To find out if the combination of vitamin C and chemo is safe and works well to treat Hodgkin lymphoma or NHL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have lymphoma or chronic myelomonocytic leukemia (CMML)
- Do not have paroxysmal nocturnal hemoglobinuria (PNH)
- Do not have untreated lymphoma in your brain or spinal cord
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
In this trial, you’ll be randomized to 1 of 3 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
- Group 1 – vitamin C
- Group 2 – vitamin C plus chemo
- Group 3 – placebo plus chemo
Randomized means doctors will use a computer to assign you to a group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You’ll get treatment in cycles that last 3 weeks. In each cycle, you'll get:
- Chemo drugs – Groups 2 and 3 only – Given as intravenous (IV) infusions or a pill that you take by mouth. The drugs and doses you'll get depends on your group
- Placebo – Group 3 only – Given as IV infusions with no medicine in it 3 times each week
- Vitamin C – Groups 1 and 2 only – Given as IV infusions 3 times each week
Chemo drugs you may receive include:
- Carboplatin
- Cisplatin
- Cytarabine
- Dexamethasone
- Etoposide
- Gemcitabine Hydrochloride
- Ifosfamide
- Oxaliplatin
- Rituximab
You may continue treatment for up to 3 months. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 2 years.
The Food and Drug Administration (FDA) has approved all of the drugs used in this trial. Using vitamin C in combination with chemo to treat lymphoma is new and unproven.
Locations
Mayo Clinic Health Systems-MankatoNOT_YET_RECRUITING
Mankato, Minnesota
Danielle Mutschler, 507-377-4817, Mutschler.Danielle@mayo.edu
Mayo Clinic in RochesterRECRUITING
Rochester, Minnesota
Clinical Trials Referral Office, 855-776-0015, mayocliniccancerstudies@mayo.edu
Mayo Clinic Health System-Franciscan HealthcareACTIVE_NOT_RECRUITING
La Crosse, Wisconsin
Mayo Clinic Health System-Eau Claire ClinicNOT_YET_RECRUITING
Eau Claire, Wisconsin
Clinical Trials Referral Office, 855-776-0015, mayocliniccancerstudies@mayo.edu
Sponsors
collaborator: National Cancer Institute (NCI), lead: Mayo Clinic
