Clinical Trial Goal
To find out:
- The highest dose of CB-011 that's safe to give
- If CB-011 CAR T cells are safe and work well to treat multiple myeloma that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have multiple myeloma that has relapsed or is refractory
- Have been treated with at least 3 treatments for the myeloma
- Have not had an autologous (your own cells) blood or marrow transplant (BMT) in the last 1.5 months
- Have not had an allogeneic (cells from a donor) BMT in the last 6 months
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Cyclophosphamide and fludarabine are chemotherapy (chemo) drugs that block the growth of cancer cells.
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
To make CAR T cells, T cells are collected from a donor by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with [number] of standard drugs:
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
To make CAR T cells, T cells are collected from a donor by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with [number] of standard drugs:
- Cyclophosphamide– Given as intravenous (IV) infusions
- Fludarabine - Given as IV) infusions
Then, the CAR T cells (CB-011) are given to you through an IV infusion. The dose of cells you’ll get depends on when you start the trial and how safe it has been.
The clinical trial doctors will watch you closely over 1 year. You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for 15 years.
The Food and Drug Administration (FDA) has not yet approved CB-011 CAR T cells.
Watch a video about CAR T-Cell Therapy
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Locations
Sponsors
lead: Caribou Biosciences, Inc.
