Clinical Trial Goal
To find out:
- The highest dose of CB-010 that's safe to give
- If CB-010 is safe and works well to treat B-cell NHL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have B-cell NHL that has relapsed or is refractory. Some examples include:
- Burkitt lymphoma
- Chronic lymphocytic leukemia (CLL)
- Diffuse large B-cell lymphoma (DLBCL)
- Follicular lymphoma
- Mantle cell lymphoma (MCL)
- Small lymphocytic lymphoma (SLL)
- Have not been treated with therapy that targets CD19 on certain cells. Your doctor can tell you this
- Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT)
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Cyclophosphamide and fludarabine are drugs that block the growth of cancer cells.
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells. CB-010 is a type of CAR T-cell therapy that targets CD19 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified, using a technique called CRISPR, to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with 2 standard drugs:
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells. CB-010 is a type of CAR T-cell therapy that targets CD19 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified, using a technique called CRISPR, to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with 2 standard drugs:
- Cyclophosphamide – Given as intravenous (IV) infusions
- Fludarabine – Given as IV infusions
Then, the CB-010 is given to you through an IV infusion. The dose of cells you’ll get depends on when you start the trial and how safe it has been.
The clinical trial doctors will watch you closely over the first 24 hours. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.
The Food and Drug Administration (FDA) has approved some types of CAR T-cell therapy to treat B-cell NHL. The FDA has not yet approved CB-010.
Watch a video about CAR T-Cell Therapy
Locations
Sponsors
lead: Caribou Biosciences, Inc.
