Radiation therapy, given before CAR T cells, to treat large B-cell lymphoma (LBCL) that has come back (relapsed) or has not responded to previous treatment (refractory)

To find out if giving radiation therapy before CAR T cells is safe and works well to treat LBCL that has relapsed or is refractory

Doctors think radiation therapy before CAR T-cell infusion can slow disease progression after your cells are collected and before the CAR T-cell infusion. 
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.

To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
 
Before the CAR T-cell infusion, you’ll get:

Then, the CAR T cells are given to you through an IV infusion.

The clinical trial doctors will watch you closely over 1 month. You'll have biopsies and/or scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.

The Food and Drug Administration (FDA) has approved CAR T-cell therapy to treat lymphoma. Using radiation therapy before infusing CAR T cells is new and unproven.

Watch a video about CAR T-Cell Therapy
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