Clinical Trial Goal
To find out if golcadomide and rituximab before CAR T cell therapy is safe and works well to treat B-NHL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have B-cell NHL that has relapsed or is refractory. Some examples include:
- Diffuse large B-cell lymphoma (DLBCL)
- Follicular lymphoma, grade 3b
- High-grade B-cell lymphoma
- Large B-cell lymphoma with IRF4 rearrangement. Your doctor can tell you this
- Have not had allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 6 months
- Have not had autologous (your own cells) BMT in the last 3 months
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
Golcadomide is a small molecule cereblon E3 ligase modulator (CELMoD).
Rituximab is a monoclonal antibody that targets CD20 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get treatment with:
Golcadomide is a small molecule cereblon E3 ligase modulator (CELMoD).
Rituximab is a monoclonal antibody that targets CD20 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get treatment with:
- Golcadomide – A pill that you take by mouth 1 time each day for 2 weeks
- Rituximab – Given as intravenous (IV) infusions up to 1 time each week
Then, the CAR T cells are given to you through an IV infusion.
The clinical trial doctors will watch you closely over 2 years. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.
The Food and Drug Administration (FDA) has not yet approved golcadomide.
Watch a video about CAR T-Cell Therapy
Locations
Sponsors
lead: Mayo Clinic
