Clinical Trial Goal
To find out if losartan is safe and works well to treat diffuse myocardial fibrosis in children and adults with SCD
You may be able to join this trial if you:
- Are 6 years or older
- Have one of the following:
- SCD (HbSS)
- Beta-thalassemia
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Losartan is an angiotensin II receptor blocker that doctors think may help in stabilizing or decreasing extracellular volume fraction (ECV)/diffuse myocardial fibrosis in patients with SCD.
You’ll get:
You’ll get:
- Losartan – A pill that you take by mouth 1 time each day
You may continue treatment for up to 1 year. The clinical trial doctors will check your health for 2 years.
The Food and Drug Administration (FDA) has approved losartan to treat high blood pressure and reduce the risk of strokes. Using it to treat diffuse myocardial fibrosis in patients with SCD is new and unproven.
Contacts
Omar Niss, MD, (513) 803-7545, omar.niss@cchmc.org
Amanda Pfeiffer, (513) 803-4977, amanda.pfeiffer@cchmc.org
Locations
Cincinnati Children's Hospital Medical CenterRECRUITING
Cincinnati, Ohio
Contacts:
- Amanda Pfeiffer, (513) 803-4977, Amanda.Pfeiffer@cchmc.org
- Amy Shova, (513)803-1917, Amy.Shova@cchmc.org
Sponsors
lead: Children's Hospital Medical Center, Cincinnati
