Clinical Trial Goal
To find out if MB-105 is safe and works well to treat CD5+ CTCL or PTCL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have CD5+ CTCL or PTCL that has relapsed or is refractory. Your doctor can tell you this
- Do not have Sezary syndrome
- Do not have lymphoma in your brain or spinal cord
- Do not have acute graft-versus-host-disease (aGVHD)
- Have not been treated with any of the following in the last 2 months:
- Allogeneic (cells from a donor) blood or marrow transplant (BMT)
- Autologous (your own cells) BMT
- CAR T-cell therapy
- Have not been treated with a drug that targets CD5. Your doctor can tell you this
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
MB-105 is a type of CAR T-cell therapy that targets CD5 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with standard drugs.
MB-105 is a type of CAR T-cell therapy that targets CD5 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with standard drugs.
Then, the CAR T cells are given to you through an IV infusion.
The clinical trial doctors will watch you closely for about 2 years. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.
The Food and Drug Administration (FDA) has not yet approved MB-105.
Watch a video about CAR T-Cell Therapy
Locations
Sponsors
lead: March Biosciences Inc
