Clinical Trial Goal
To find out:
- The highest dose of P-CD19CD20-ALLO1 that's safe to give
- If P-CD19CD20-ALLO1 are safe and work well to treat B-cell leukemia and B-cell lymphoma that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years or older
- Have one of the following that has relapsed or is refractory:
- Chronic lymphocytic leukemia (CLL)
- Diffuse large B-cell lymphoma (DLBCL)
- Follicular lymphoma
- Primary mediastinal large B-cell lymphoma (PMBCL)
- Have cancer cells with one of the following markers:
- CD5
- CD19
- CD20
- CD23
- Have not had an autologous (your own cells) blood or marrow transplant (BMT) in the last 3 months
- Have not had autologous CAR T-cell therapy in the last 3 months
- Do not have lymphoma in your brain or spinal cord
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
Rimiducid is a safety switch activator that helps control CAR T- cells.
To make CAR T cells, T cells are collected from a donor by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with standard drugs.
Rimiducid is a safety switch activator that helps control CAR T- cells.
To make CAR T cells, T cells are collected from a donor by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get chemotherapy (chemo) with standard drugs.
Then, the CAR T cells are given to you through an IV infusion. The dose of cells you’ll get depends on when you start the trial and how safe it has been.
The clinical trial doctors will watch you closely over 3 years. You'll have biopsies and/or scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.
The Food and Drug Administration (FDA) has not yet approved P-CD19CD20-ALLO1.
Watch a video about CAR T-Cell Therapy
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Locations
Sponsors
collaborator: Roche-Genentech, lead: Poseida Therapeutics, Inc.
