Testing cancer genes to choose treatments for children with non-Hodgkin lymphoma (NHL) or histiocytosis that has come back (relapsed) or has not gotten better with treatment (refractory), in children and young adults
PrintClinical Trial Goal
You may be able to join this trial if you:
- Is 12 months – 21 years old
- Has NHL or histiocytosis that has relapsed or is refractory
- Has not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
- You agree to have other standard tests done to see if your child can be in the clinical trial
Trial Details
Here are some of the drugs being used in this trial. These are all pills that your child would take by mouth 1 or 2 times each day:
- Ensartinib
- Erdafitinib
- JNJ-42756493
- Larotrectinib (LOXO-101)
- Olaparib
- Palbociclib
- Samotolisib
- Selumetinib
- Tazemetostat
- Ulixertinib
- Vemurafenib
Your child may get treatment for up to 2 years. The clinical trial doctors will check your child’s health for up to 4 years.
The Food and Drug Administration (FDA) has approved olaparib, palbociclib and vemurafenib to treat other cancers. Using these drugs to treat NHL is new and unproven. The FDA has not yet approved ensartinib, erdafitinib, JNJ-42756493, larotrectinib, samotolisib, selumetinib, ulixertinib and tazemetostat. Using the results of cancer gene tests to choose the best treatment for NHL is new and unproven.
Locations
Children's Hospital of AlabamaRecruiting
Birmingham, Alabama
Site Public Contact, 205-638-9285, oncologyresearch@peds.uab.edu
Providence Alaska Medical CenterRecruiting
Anchorage, Alaska
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org
Banner Children's at DesertRecruiting
Mesa, Arizona
Site Public Contact, 480-412-3100
Banner University Medical Center - TucsonRecruiting
Tucson, Arizona
Site Public Contact, UACC-IIT@uacc.arizona.edu
Phoenix Childrens HospitalRecruiting
Phoenix, Arizona
Site Public Contact, 602-546-0920
Arkansas Children's HospitalRecruiting
Little Rock, Arkansas
Site Public Contact, 501-364-7373
City of Hope Comprehensive Cancer CenterActive, not recruiting
Duarte, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterActive, not recruiting
Torrance, California
Cedars Sinai Medical CenterRecruiting
Los Angeles, California
Site Public Contact, 310-423-8965
Children's Hospital Los AngelesRecruiting
Los Angeles, California
Site Public Contact, 323-361-4110
Children's Hospital of Orange CountyRecruiting
Orange, California
Site Public Contact, 714-509-8646, oncresearch@choc.org
Kaiser Permanente Downey Medical CenterRecruiting
Downey, California
Site Public Contact, 626-564-3455
Kaiser Permanente-OaklandRecruiting
Oakland, California
Site Public Contact, 877-642-4691, Kpoct@kp.org
Loma Linda University Medical CenterRecruiting
Loma Linda, California
Site Public Contact, 909-558-4050
Lucile Packard Children's Hospital Stanford UniversityRecruiting
Palo Alto, California
Site Public Contact, 800-694-0012, ccto-office@stanford.edu
Mattel Children's Hospital UCLARecruiting
Los Angeles, California
Site Public Contact, 310-825-6708
Miller Children's and Women's Hospital Long BeachRecruiting
Long Beach, California
Site Public Contact, 562-933-5600
Naval Medical Center -San DiegoRecruiting
San Diego, California
Site Public Contact, 619-532-8712
Rady Children's Hospital - San DiegoRecruiting
San Diego, California
Site Public Contact, 858-966-5934
UCSF Benioff Children's Hospital OaklandRecruiting
Oakland, California
Site Public Contact, 510-428-3264, cogbchoak@ucsf.edu
UCSF Medical Center-Mission BayRecruiting
San Francisco, California
Site Public Contact, 877-827-3222, cancertrials@ucsf.edu
University of California Davis Comprehensive Cancer CenterRecruiting
Sacramento, California
Site Public Contact, 916-734-3089
Valley Children's HospitalRecruiting
Madera, California
Site Public Contact, 559-353-3000, Research@valleychildrens.org
Children's Hospital ColoradoRecruiting
Aurora, Colorado
Site Public Contact, 303-764-5056, josh.b.gordon@nsmtp.kp.org
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterRecruiting
Denver, Colorado
Site Public Contact, 303-839-6000
Connecticut Children's Medical CenterRecruiting
Hartford, Connecticut
Site Public Contact, 860-545-9981
Yale UniversityRecruiting
New Haven, Connecticut
Site Public Contact, 203-785-5702, canceranswers@yale.edu
Alfred I duPont Hospital for ChildrenRecruiting
Wilmington, Delaware
Site Public Contact, 302-651-5572, Allison.bruce@nemours.org
Children's National Medical CenterRecruiting
Washington, District of Columbia
Site Public Contact, 202-476-2800, OncCRC_OnCall@childrensnational.org
MedStar Georgetown University HospitalRecruiting
Washington, District of Columbia
Site Public Contact, 202-444-2223
Nemours Children's Clinic - PensacolaActive, not recruiting
Pensacola, Florida
Saint Joseph's Hospital/Children's Hospital-TampaActive, not recruiting
Tampa, Florida
AdventHealth OrlandoRecruiting
Orlando, Florida
Site Public Contact, 407-303-2090, FH.Cancer.Research@flhosp.org
Arnold Palmer Hospital for ChildrenRecruiting
Orlando, Florida
Site Public Contact, 321-841-5357, Jennifer.spinelli@orlandohealth.com
Broward Health Medical CenterRecruiting
Fort Lauderdale, Florida
Site Public Contact, 302-651-5572, Allison.bruce@nemours.org
Golisano Children's Hospital of Southwest FloridaRecruiting
Fort Myers, Florida
Site Public Contact, 239-343-5333, molly.arnstrom@leehealth.org
Johns Hopkins All Children's HospitalRecruiting
Saint Petersburg, Florida
Site Public Contact, 727-767-4784, Ashley.Repp@jhmi.edu
Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting
Hollywood, Florida
Site Public Contact, 954-265-1847, OHR@mhs.net
Nemours Children's Clinic-JacksonvilleRecruiting
Jacksonville, Florida
Site Public Contact, 302-651-5572, Allison.bruce@nemours.org
Nemours Children's HospitalRecruiting
Orlando, Florida
Site Public Contact, 302-651-5572, Allison.bruce@nemours.org
Nicklaus Children's HospitalRecruiting
Miami, Florida
Site Public Contact, 888-624-2778
Sacred Heart HospitalRecruiting
Pensacola, Florida
Site Public Contact, 850-416-4611, eebrou@ascension.org
Saint Mary's HospitalRecruiting
West Palm Beach, Florida
Site Public Contact, 561-881-2815
Tampa General HospitalRecruiting
Tampa, Florida
Site Public Contact, 813-844-7829, syapchanyk@tgh.org
University of Florida Health Science Center - GainesvilleRecruiting
Gainesville, Florida
Site Public Contact, 352-273-8010, cancer-center@ufl.edu
University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting
Miami, Florida
Site Public Contact, 305-243-2647
Children's Healthcare of Atlanta - EglestonRecruiting
Atlanta, Georgia
Site Public Contact, 404-785-2025, Leann.Schilling@choa.org
Memorial Health University Medical CenterRecruiting
Savannah, Georgia
Site Public Contact, 912-350-7887, Lorraine.OHara@hcahealthcare.com
Kapiolani Medical Center for Women and ChildrenRecruiting
Honolulu, Hawaii
Site Public Contact, 808-983-6090
Saint Luke's Cancer Institute - BoiseRecruiting
Boise, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org
Loyola University Medical CenterRecruiting
Maywood, Illinois
Site Public Contact, 708-226-4357
Lurie Children's Hospital-ChicagoRecruiting
Chicago, Illinois
Site Public Contact, 773-880-4562
Saint Jude Midwest AffiliateRecruiting
Peoria, Illinois
Site Public Contact, 888-226-4343
Southern Illinois University School of MedicineRecruiting
Springfield, Illinois
Site Public Contact, 217-545-7929
University of Chicago Comprehensive Cancer CenterRecruiting
Chicago, Illinois
Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu
University of IllinoisRecruiting
Chicago, Illinois
Site Public Contact, 312-355-3046
Ascension Saint Vincent Indianapolis HospitalRecruiting
Indianapolis, Indiana
Site Public Contact, 317-338-2194, research@stvincent.org
Riley Hospital for ChildrenRecruiting
Indianapolis, Indiana
Site Public Contact, 800-248-1199
Blank Children's HospitalRecruiting
Des Moines, Iowa
Site Public Contact, 515-241-8912, samantha.mallory@unitypoint.org
University of Iowa/Holden Comprehensive Cancer CenterRecruiting
Iowa City, Iowa
Site Public Contact, 800-237-1225
Norton Children's HospitalRecruiting
Louisville, Kentucky
Site Public Contact, 502-629-5500, CancerResource@nortonhealthcare.org
University of Kentucky/Markey Cancer CenterRecruiting
Lexington, Kentucky
Site Public Contact, 859-257-3379
Children's Hospital New OrleansRecruiting
New Orleans, Louisiana
Site Public Contact, CHResearch@lcmchealth.org
Ochsner Medical Center JeffersonRecruiting
New Orleans, Louisiana
Site Public Contact, 504-842-8084, Elisemarie.curry@ochsner.org
Eastern Maine Medical CenterRecruiting
Bangor, Maine
Site Public Contact, 207-973-4274
Maine Children's Cancer ProgramRecruiting
Scarborough, Maine
Site Public Contact, 207-396-7581, sverwys@mmc.org
National Institutes of Health Clinical CenterActive, not recruiting
Bethesda, Maryland
Johns Hopkins University/Sidney Kimmel Cancer CenterRecruiting
Baltimore, Maryland
Site Public Contact, 410-955-8804, jhcccro@jhmi.edu
Sinai Hospital of BaltimoreRecruiting
Baltimore, Maryland
Site Public Contact, 410-601-6120, pridgely@lifebridgehealth.org
University of Maryland/Greenebaum Cancer CenterRecruiting
Baltimore, Maryland
Site Public Contact, 800-888-8823
Dana-Farber Cancer InstituteRecruiting
Boston, Massachusetts
Site Public Contact, 877-442-3324
Massachusetts General Hospital Cancer CenterRecruiting
Boston, Massachusetts
Site Public Contact, 877-726-5130
UMass Memorial Medical Center - University CampusRecruiting
Worcester, Massachusetts
Site Public Contact, 508-856-3216, cancer.research@umassmed.edu
Wayne State University/Karmanos Cancer InstituteActive, not recruiting
Detroit, Michigan
Beaumont Children's Hospital-Royal OakRecruiting
Royal Oak, Michigan
Site Public Contact, 248-551-7695
Bronson Methodist HospitalRecruiting
Kalamazoo, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org
Children's Hospital of MichiganRecruiting
Detroit, Michigan
Site Public Contact, helpdesk@childrensoncologygroup.org
C S Mott Children's HospitalRecruiting
Ann Arbor, Michigan
Site Public Contact, 800-865-1125
Helen DeVos Children's Hospital at Spectrum HealthRecruiting
Grand Rapids, Michigan
Site Public Contact, 616-267-1925, crcwm-regulatory@crcwm.org
Michigan State University Clinical CenterRecruiting
East Lansing, Michigan
Site Public Contact, 517-975-9547
Children's Hospitals and Clinics of Minnesota - MinneapolisRecruiting
Minneapolis, Minnesota
Site Public Contact, 612-813-5913, pauline.mitby@childrensmn.org
Mayo Clinic in RochesterRecruiting
Rochester, Minnesota
Site Public Contact, 855-776-0015
University of Minnesota/Masonic Cancer CenterRecruiting
Minneapolis, Minnesota
Site Public Contact, 612-624-2620
University of Mississippi Medical CenterRecruiting
Jackson, Mississippi
Site Public Contact, 601-815-6700
Cardinal Glennon Children's Medical CenterRecruiting
Saint Louis, Missouri
Site Public Contact, 314-268-4000
Children's Mercy Hospitals and ClinicsRecruiting
Kansas City, Missouri
Site Public Contact, 816-302-6808, rryan@cmh.edu
Mercy Hospital Saint LouisRecruiting
Saint Louis, Missouri
Site Public Contact, 314-251-7066
Washington University School of MedicineRecruiting
Saint Louis, Missouri
Site Public Contact, 800-600-3606, info@siteman.wustl.edu
Children's Hospital and Medical Center of OmahaRecruiting
Omaha, Nebraska
Site Public Contact, 402-955-3949
University of Nebraska Medical CenterRecruiting
Omaha, Nebraska
Site Public Contact, 402-559-6941, unmcrsa@unmc.edu
Alliance for Childhood Diseases/Cure 4 the Kids FoundationRecruiting
Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org
Summerlin Hospital Medical CenterRecruiting
Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org
Sunrise Hospital and Medical CenterRecruiting
Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org
University Medical Center of Southern NevadaSuspended
Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterRecruiting
Lebanon, New Hampshire
Site Public Contact, 800-639-6918, cancer.research.nurse@dartmouth.edu
Hackensack University Medical CenterRecruiting
Hackensack, New Jersey
Site Public Contact, 201-996-2879
Morristown Medical CenterRecruiting
Morristown, New Jersey
Site Public Contact, 973-971-5900
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalRecruiting
New Brunswick, New Jersey
Site Public Contact, 732-235-8675
Saint Peter's University HospitalRecruiting
New Brunswick, New Jersey
Site Public Contact, 732-745-8600, kcovert@saintpetersuh.com
NYU Winthrop HospitalActive, not recruiting
Mineola, New York
Albany Medical CenterRecruiting
Albany, New York
Site Public Contact, 518-262-5513
Laura and Isaac Perlmutter Cancer Center at NYU LangoneRecruiting
New York, New York
Site Public Contact, CancerTrials@nyulangone.org
Memorial Sloan Kettering Cancer CenterRecruiting
New York, New York
Site Public Contact, 212-639-7592
Montefiore Medical Center - Moses CampusRecruiting
Bronx, New York
Site Public Contact, 718-379-6866, eskwak@montefiore.org
New York Medical CollegeRecruiting
Valhalla, New York
Site Public Contact, 914-594-3794
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterRecruiting
New York, New York
Site Public Contact, 212-342-5162, cancerclinicaltrials@cumc.columbia.edu
NYP/Weill Cornell Medical CenterRecruiting
New York, New York
Site Public Contact, 212-746-1848
Roswell Park Cancer InstituteRecruiting
Buffalo, New York
Site Public Contact, 800-767-9355, askroswell@roswellpark.org
State University of New York Upstate Medical UniversityRecruiting
Syracuse, New York
Site Public Contact, 315-464-5476
Stony Brook University Medical CenterRecruiting
Stony Brook, New York
Site Public Contact, 800-862-2215
The Steven and Alexandra Cohen Children's Medical Center of New YorkRecruiting
New Hyde Park, New York
Site Public Contact, 718-470-3460
University of RochesterRecruiting
Rochester, New York
Site Public Contact, 585-275-5830
Carolinas Medical Center/Levine Cancer InstituteRecruiting
Charlotte, North Carolina
Site Public Contact, 800-804-9376
Duke University Medical CenterRecruiting
Durham, North Carolina
Site Public Contact, 888-275-3853
East Carolina UniversityRecruiting
Greenville, North Carolina
Site Public Contact, 252-744-1015, eubankss@ecu.edu
Mission HospitalRecruiting
Asheville, North Carolina
Site Public Contact, 828-213-7055, NCDV.ResearchRegulatory@HCAHealthcare.com
Novant Health Presbyterian Medical CenterRecruiting
Charlotte, North Carolina
Site Public Contact, 980-201-6360, kashah@novanthealth.org
UNC Lineberger Comprehensive Cancer CenterRecruiting
Chapel Hill, North Carolina
Site Public Contact, 877-668-0683, cancerclinicaltrials@med.unc.edu
Wake Forest University Health SciencesRecruiting
Winston-Salem, North Carolina
Site Public Contact, 336-713-6771
Children's Hospital Medical Center of AkronRecruiting
Akron, Ohio
Site Public Contact, 330-543-3193
Cincinnati Children's Hospital Medical CenterRecruiting
Cincinnati, Ohio
Site Public Contact, 513-636-2799, cancer@cchmc.org
Cleveland Clinic FoundationRecruiting
Cleveland, Ohio
Site Public Contact, 866-223-8100, TaussigResearch@ccf.org
Dayton Children's HospitalRecruiting
Dayton, Ohio
Site Public Contact, 800-228-4055
Nationwide Children's HospitalRecruiting
Columbus, Ohio
Site Public Contact, 614-722-6039, Melinda.Triplet@nationwidechildrens.org
ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalRecruiting
Toledo, Ohio
Site Public Contact, 419-824-1842, PCIOncResearch@promedica.org
Rainbow Babies and Childrens HospitalRecruiting
Cleveland, Ohio
Site Public Contact, 216-844-5437
University of Oklahoma Health Sciences CenterRecruiting
Oklahoma City, Oklahoma
Site Public Contact, 405-271-8777, ou-clinical-trials@ouhsc.edu
Legacy Emanuel Children's HospitalRecruiting
Portland, Oregon
Site Public Contact, 503-413-2560
Oregon Health and Science UniversityRecruiting
Portland, Oregon
Site Public Contact, 503-494-1080, trials@ohsu.edu
Children's Hospital of PhiladelphiaRecruiting
Philadelphia, Pennsylvania
Site Public Contact, 267-425-5544, CancerTrials@email.chop.edu
Children's Hospital of Pittsburgh of UPMCRecruiting
Pittsburgh, Pennsylvania
Site Public Contact, 412-692-8570, jean.tersak@chp.edu
Geisinger Medical CenterRecruiting
Danville, Pennsylvania
Site Public Contact, 570-271-5251, HemonCCTrials@geisinger.edu
Lehigh Valley Hospital-Cedar CrestRecruiting
Allentown, Pennsylvania
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org
Rhode Island HospitalRecruiting
Providence, Rhode Island
Site Public Contact, 401-444-1488
BI-LO Charities Children's Cancer CenterRecruiting
Greenville, South Carolina
Site Public Contact, 864-241-6251
Prisma Health Richland HospitalRecruiting
Columbia, South Carolina
Site Public Contact, 864-241-6251
Sanford USD Medical Center - Sioux FallsRecruiting
Sioux Falls, South Dakota
Site Public Contact, 605-312-3320, OncologyClinicalTrialsSF@SanfordHealth.org
East Tennessee Childrens HospitalRecruiting
Knoxville, Tennessee
Site Public Contact, 865-541-8266
Saint Jude Children's Research HospitalRecruiting
Memphis, Tennessee
Site Public Contact, 888-226-4343, referralinfo@stjude.org
The Children's Hospital at TriStar CentennialRecruiting
Nashville, Tennessee
Site Public Contact, 615-342-1919
Vanderbilt University/Ingram Cancer CenterRecruiting
Nashville, Tennessee
Site Public Contact, 800-811-8480
M D Anderson Cancer CenterCompleted
Houston, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting
Houston, Texas
Site Public Contact, 713-798-1354, burton@bcm.edu
Children's Hospital of San AntonioRecruiting
San Antonio, Texas
Site Public Contact, 210-704-2894, bridget.medina@christushealth.org
Cook Children's Medical CenterRecruiting
Fort Worth, Texas
Site Public Contact, 682-885-2103, CookChildrensResearch@cookchildrens.org
Covenant Children's HospitalRecruiting
Lubbock, Texas
Site Public Contact, 806-725-8657, mbisbee@providence.org
Dell Children's Medical Center of Central TexasRecruiting
Austin, Texas
Site Public Contact, 512-628-1902, TXAUS-DL-SFCHemonc.research@ascension.org
Driscoll Children's HospitalRecruiting
Corpus Christi, Texas
Site Public Contact, 361-694-5311, Crystal.DeLosSantos@dchstx.org
El Paso Children's HospitalRecruiting
El Paso, Texas
Site Public Contact, 915-298-5444, ranjan.bista@ttuhsc.edu
Medical City Dallas HospitalRecruiting
Dallas, Texas
Site Public Contact, 972-566-5588
Methodist Children's Hospital of South TexasRecruiting
San Antonio, Texas
Site Public Contact, 210-575-6240, Vinod.GidvaniDiaz@hcahealthcare.com
Scott and White Memorial HospitalRecruiting
Temple, Texas
Site Public Contact, 254-724-5407
UMC Cancer Center / UMC Health SystemRecruiting
Lubbock, Texas
Site Public Contact, 806-775-8590
University of Texas Health Science Center at San AntonioRecruiting
San Antonio, Texas
Site Public Contact, 210-450-3800, phoresearchoffice@uthscsa.edu
UT Southwestern/Simmons Cancer Center-DallasRecruiting
Dallas, Texas
Site Public Contact, 214-648-7097, canceranswerline@UTSouthwestern.edu
Primary Children's HospitalRecruiting
Salt Lake City, Utah
Site Public Contact, 801-585-5270
University of Vermont and State Agricultural CollegeRecruiting
Burlington, Vermont
Site Public Contact, 802-656-8990, rpo@uvm.edu
Children's Hospital of The King's DaughtersRecruiting
Norfolk, Virginia
Site Public Contact, 757-668-7243, CCBDCresearch@chkd.org
Naval Medical Center - PortsmouthRecruiting
Portsmouth, Virginia
Site Public Contact, 757-953-5939
Virginia Commonwealth University/Massey Cancer CenterRecruiting
Richmond, Virginia
Site Public Contact, CTOclinops@vcu.edu
Madigan Army Medical CenterRecruiting
Tacoma, Washington
Site Public Contact, 253-968-6144, melissa.a.forouhar.mil@health.mil
Mary Bridge Children's Hospital and Health CenterRecruiting
Tacoma, Washington
Site Public Contact, 253-403-1461, research@multicare.org
Providence Sacred Heart Medical Center and Children's HospitalRecruiting
Spokane, Washington
Site Public Contact, 800-228-6618, HopeBeginsHere@providence.org
Seattle Children's HospitalRecruiting
Seattle, Washington
Site Public Contact, 866-987-2000
West Virginia University HealthcareActive, not recruiting
Morgantown, West Virginia
Children's Hospital of WisconsinRecruiting
Milwaukee, Wisconsin
Site Public Contact, 414-955-4727, MACCCTO@mcw.edu
Marshfield Medical Center-MarshfieldRecruiting
Marshfield, Wisconsin
Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org
University of Wisconsin Carbone Cancer CenterRecruiting
Madison, Wisconsin
Site Public Contact, 800-622-8922, clinicaltrials@cancer.wisc.edu
Sponsors
lead: National Cancer Institute (NCI)
