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Testing cancer genes to choose treatments for children with non-Hodgkin lymphoma (NHL) or histiocytosis that has come back (relapsed) or has not gotten better with treatment (refractory), in children and young adults

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12 months - 21

Phase 2

163 Locations

NCT03155620

Clinical Trial Goal


To find out if testing cancer genes works well to choose specific treatments for NHL or histiocytosis that has relapsed or is refractory in children and young adults

You may be able to join this trial if you:


Your child:
  • Is 12 months – 21 years old
  • Has NHL or histiocytosis that has relapsed or is refractory 
  • Has not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
  • You agree to have other standard tests done to see if your child can be in the clinical trial

Trial Details


First, your child will have a biopsy to find out what gene mutations are in the NHL. The clinical trial doctors will use this information to choose a drug that is most likely to work well.

Here are some of the drugs being used in this trial. These are all pills that your child would take by mouth 1 or 2 times each day:
  • Ensartinib
  • Erdafitinib
  • JNJ-42756493
  • Larotrectinib (LOXO-101)
  • Olaparib
  • Palbociclib
  • Samotolisib
  • Selumetinib
  • Tazemetostat
  • Ulixertinib
  • Vemurafenib

Your child may get treatment for up to 2 years. The clinical trial doctors will check your child’s health for up to 4 years.

The Food and Drug Administration (FDA) has approved olaparib, palbociclib and vemurafenib to treat other cancers. Using these drugs to treat NHL is new and unproven. The FDA has not yet approved ensartinib, erdafitinib, JNJ-42756493, larotrectinib, samotolisib, selumetinib, ulixertinib and tazemetostat. Using the results of cancer gene tests to choose the best treatment for NHL is new and unproven.

Locations

Children's Hospital of AlabamaRecruiting

Birmingham, Alabama
Site Public Contact, 205-638-9285, oncologyresearch@peds.uab.edu

Providence Alaska Medical CenterRecruiting

Anchorage, Alaska
Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

Banner Children's at DesertRecruiting

Mesa, Arizona
Site Public Contact, 480-412-3100

Banner University Medical Center - TucsonRecruiting

Tucson, Arizona
Site Public Contact, UACC-NCTN@uacc.arizona.edu

Phoenix Childrens HospitalRecruiting

Phoenix, Arizona
Site Public Contact, 602-546-0920

Arkansas Children's HospitalRecruiting

Little Rock, Arkansas
Site Public Contact, 501-364-7373

Cedars Sinai Medical CenterRecruiting

Los Angeles, California
Site Public Contact, 310-423-8965

Children's Hospital Los AngelesRecruiting

Los Angeles, California
Site Public Contact, 323-361-4110

Children's Hospital of Orange CountyRecruiting

Orange, California
Site Public Contact, 714-509-8646, oncresearch@choc.org

City of Hope Comprehensive Cancer CenterRecruiting

Duarte, California
Site Public Contact, 800-826-4673, becomingapatient@coh.org

Kaiser Permanente Downey Medical CenterRecruiting

Downey, California
Site Public Contact, 626-564-3455

Kaiser Permanente-OaklandRecruiting

Oakland, California
Site Public Contact, 877-642-4691, Kpoct@kp.org

Loma Linda University Medical CenterRecruiting

Loma Linda, California
Site Public Contact, 909-558-4050

Lucile Packard Children's Hospital Stanford UniversityRecruiting

Palo Alto, California
Site Public Contact, 800-694-0012, ccto-office@stanford.edu

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterRecruiting

Torrance, California
Site Public Contact, 310-222-3624, irb@lundquist.org

Mattel Children's Hospital UCLARecruiting

Los Angeles, California
Site Public Contact, 310-825-6708

Miller Children's and Women's Hospital Long BeachRecruiting

Long Beach, California
Site Public Contact, 562-933-5600

Naval Medical Center -San DiegoRecruiting

San Diego, California
Site Public Contact, 619-532-8712

Rady Children's Hospital - San DiegoRecruiting

San Diego, California
Site Public Contact, 858-966-5934

UCSF Benioff Children's Hospital OaklandRecruiting

Oakland, California
Site Public Contact, 510-428-3324, Carla.Golden@ucsf.edu

UCSF Medical Center-Mission BayRecruiting

San Francisco, California
Site Public Contact, 877-827-3222

University of California Davis Comprehensive Cancer CenterRecruiting

Sacramento, California
Site Public Contact, 916-734-3089

Valley Children's HospitalRecruiting

Madera, California
Site Public Contact, 559-353-3000, Research@valleychildrens.org

Children's Hospital ColoradoRecruiting

Aurora, Colorado
Site Public Contact, 303-764-5056, josh.b.gordon@nsmtp.kp.org

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterRecruiting

Denver, Colorado
Site Public Contact, 303-839-6000

Connecticut Children's Medical CenterRecruiting

Hartford, Connecticut
Site Public Contact, 860-545-9981

Yale UniversityRecruiting

New Haven, Connecticut
Site Public Contact, 203-785-5702, canceranswers@yale.edu

Alfred I duPont Hospital for ChildrenRecruiting

Wilmington, Delaware
Site Public Contact, 302-651-6884, dperry@nemours.org

Children's National Medical CenterRecruiting

Washington, District of Columbia
Site Public Contact, 202-884-2549

MedStar Georgetown University HospitalRecruiting

Washington, District of Columbia
Site Public Contact, 202-444-2223

Nemours Children's Clinic - PensacolaActive, not recruiting

Pensacola, Florida

Saint Joseph's Hospital/Children's Hospital-TampaActive, not recruiting

Tampa, Florida

AdventHealth OrlandoRecruiting

Orlando, Florida
Site Public Contact, 407-303-2090, FH.Cancer.Research@flhosp.org

Arnold Palmer Hospital for ChildrenRecruiting

Orlando, Florida
Site Public Contact, 321-841-2008, melissa.leffin@orlandohealth.com

Broward Health Medical CenterRecruiting

Fort Lauderdale, Florida
Site Public Contact, 954-355-5346

Golisano Children's Hospital of Southwest FloridaRecruiting

Fort Myers, Florida
Site Public Contact, 239-343-5333, molly.arnstrom@leehealth.org

Johns Hopkins All Children's HospitalRecruiting

Saint Petersburg, Florida
Site Public Contact, 727-767-4784, Ashley.Repp@jhmi.edu

Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting

Hollywood, Florida
Site Public Contact, 954-265-1847, OHR@mhs.net

Nemours Children's Clinic-JacksonvilleRecruiting

Jacksonville, Florida
Site Public Contact, 904-697-3529

Nemours Children's HospitalRecruiting

Orlando, Florida
Site Public Contact, 407-650-7715

Nicklaus Children's HospitalRecruiting

Miami, Florida
Site Public Contact, 888-624-2778

Sacred Heart HospitalRecruiting

Pensacola, Florida
Site Public Contact, 850-416-4611, eebrou@ascension.org

Saint Mary's HospitalRecruiting

West Palm Beach, Florida
Site Public Contact, 561-881-2815

Tampa General HospitalRecruiting

Tampa, Florida
Site Public Contact, 813-844-7829, syapchanyk@tgh.org

University of Florida Health Science Center - GainesvilleRecruiting

Gainesville, Florida
Site Public Contact, 352-273-8010, cancer-center@ufl.edu

University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting

Miami, Florida
Site Public Contact, 305-243-2647

Children's Healthcare of Atlanta - EglestonRecruiting

Atlanta, Georgia
Site Public Contact, 404-785-2025, Leann.Schilling@choa.org

Memorial Health University Medical CenterRecruiting

Savannah, Georgia
Site Public Contact, 912-350-7887, Lorraine.OHara@hcahealthcare.com

Kapiolani Medical Center for Women and ChildrenRecruiting

Honolulu, Hawaii
Site Public Contact, 808-983-6090

Saint Luke's Cancer Institute - BoiseRecruiting

Boise, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org

Loyola University Medical CenterRecruiting

Maywood, Illinois
Site Public Contact, 708-226-4357

Lurie Children's Hospital-ChicagoRecruiting

Chicago, Illinois
Site Public Contact, 773-880-4562

Saint Jude Midwest AffiliateRecruiting

Peoria, Illinois
Site Public Contact, 888-226-4343

Southern Illinois University School of MedicineRecruiting

Springfield, Illinois
Site Public Contact, 217-545-7929

University of Chicago Comprehensive Cancer CenterRecruiting

Chicago, Illinois
Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu

University of IllinoisRecruiting

Chicago, Illinois
Site Public Contact, 312-355-3046

Riley Hospital for ChildrenRecruiting

Indianapolis, Indiana
Site Public Contact, 800-248-1199

Saint Vincent Hospital and Health Care CenterRecruiting

Indianapolis, Indiana
Site Public Contact, 317-338-2194, research@stvincent.org

Blank Children's HospitalRecruiting

Des Moines, Iowa
Site Public Contact, 515-241-8912, samantha.mallory@unitypoint.org

University of Iowa/Holden Comprehensive Cancer CenterRecruiting

Iowa City, Iowa
Site Public Contact, 800-237-1225

Norton Children's HospitalRecruiting

Louisville, Kentucky
Site Public Contact, 502-629-5500, CancerResource@nortonhealthcare.org

University of Kentucky/Markey Cancer CenterRecruiting

Lexington, Kentucky
Site Public Contact, 859-257-3379

Children's Hospital New OrleansRecruiting

New Orleans, Louisiana
Site Public Contact, CHResearch@lcmchealth.org

Ochsner Medical Center JeffersonRecruiting

New Orleans, Louisiana
Site Public Contact, 504-842-8084, Elisemarie.curry@ochsner.org

Eastern Maine Medical CenterRecruiting

Bangor, Maine
Site Public Contact, 207-973-4274

Maine Children's Cancer ProgramRecruiting

Scarborough, Maine
Site Public Contact, 207-396-7581, sverwys@mmc.org

Johns Hopkins University/Sidney Kimmel Cancer CenterRecruiting

Baltimore, Maryland
Site Public Contact, 410-955-8804, jhcccro@jhmi.edu

Sinai Hospital of BaltimoreRecruiting

Baltimore, Maryland
Site Public Contact, 410-601-6120, pridgely@lifebridgehealth.org

University of Maryland/Greenebaum Cancer CenterRecruiting

Baltimore, Maryland
Site Public Contact, 800-888-8823

National Institutes of Health Clinical CenterSuspended

Bethesda, Maryland

Dana-Farber Cancer InstituteRecruiting

Boston, Massachusetts
Site Public Contact, 877-442-3324

Massachusetts General Hospital Cancer CenterRecruiting

Boston, Massachusetts
Site Public Contact, 877-726-5130

UMass Memorial Medical Center - University CampusRecruiting

Worcester, Massachusetts
Site Public Contact, 508-856-3216, cancer.research@umassmed.edu

Bronson Methodist HospitalRecruiting

Kalamazoo, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

C S Mott Children's HospitalRecruiting

Ann Arbor, Michigan
Site Public Contact, 800-865-1125

Helen DeVos Children's Hospital at Spectrum HealthRecruiting

Grand Rapids, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Wayne State University/Karmanos Cancer InstituteRecruiting

Detroit, Michigan
Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

Children's Hospitals and Clinics of Minnesota - MinneapolisRecruiting

Minneapolis, Minnesota
Site Public Contact, 612-813-5193

Mayo Clinic in RochesterRecruiting

Rochester, Minnesota
Site Public Contact, 855-776-0015

University of Minnesota/Masonic Cancer CenterRecruiting

Minneapolis, Minnesota
Site Public Contact, 612-624-2620

University of Mississippi Medical CenterRecruiting

Jackson, Mississippi
Site Public Contact, 601-815-6700

Cardinal Glennon Children's Medical CenterRecruiting

Saint Louis, Missouri
Site Public Contact, 314-268-4000

Children's Mercy Hospitals and ClinicsRecruiting

Kansas City, Missouri
Site Public Contact, 816-302-6808, rryan@cmh.edu

Mercy Hospital Saint LouisRecruiting

Saint Louis, Missouri
Site Public Contact, 314-251-7066

Washington University School of MedicineRecruiting

Saint Louis, Missouri
Site Public Contact, 800-600-3606, info@siteman.wustl.edu

Children's Hospital and Medical Center of OmahaRecruiting

Omaha, Nebraska
Site Public Contact, 402-955-3949

University of Nebraska Medical CenterRecruiting

Omaha, Nebraska
Site Public Contact, 402-559-6941, unmcrsa@unmc.edu

Alliance for Childhood Diseases/Cure 4 the Kids FoundationRecruiting

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Summerlin Hospital Medical CenterRecruiting

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Sunrise Hospital and Medical CenterRecruiting

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

University Medical Center of Southern NevadaSuspended

Las Vegas, Nevada

Dartmouth Hitchcock Medical CenterRecruiting

Lebanon, New Hampshire
Site Public Contact, 800-639-6918, cancer.research.nurse@dartmouth.edu

Hackensack University Medical CenterRecruiting

Hackensack, New Jersey
Site Public Contact, 201-996-2879

Morristown Medical CenterRecruiting

Morristown, New Jersey
Site Public Contact, 973-971-5900

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalRecruiting

New Brunswick, New Jersey
Site Public Contact, 732-235-8675

Saint Peter's University HospitalRecruiting

New Brunswick, New Jersey
Site Public Contact, 732-745-8600, kcovert@saintpetersuh.com

Albany Medical CenterRecruiting

Albany, New York
Site Public Contact, 518-262-5513

Laura and Isaac Perlmutter Cancer Center at NYU LangoneRecruiting

New York, New York
Site Public Contact, CancerTrials@nyulangone.org

Memorial Sloan Kettering Cancer CenterRecruiting

New York, New York
Site Public Contact, 212-639-7592

New York Medical CollegeRecruiting

Valhalla, New York
Site Public Contact, 914-594-3794

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterRecruiting

New York, New York
Site Public Contact, 212-305-6361, nr2616@cumc.columbia.edu

NYP/Weill Cornell Medical CenterRecruiting

New York, New York
Site Public Contact, 212-746-1848

NYU Winthrop HospitalRecruiting

Mineola, New York
Site Public Contact, CancerTrials@nyulangone.org

Roswell Park Cancer InstituteRecruiting

Buffalo, New York
Site Public Contact, 800-767-9355, askroswell@roswellpark.org

State University of New York Upstate Medical UniversityRecruiting

Syracuse, New York
Site Public Contact, 315-464-5476

Stony Brook University Medical CenterRecruiting

Stony Brook, New York
Site Public Contact, 800-862-2215

The Steven and Alexandra Cohen Children's Medical Center of New YorkRecruiting

New Hyde Park, New York
Site Public Contact, 718-470-3460

University of RochesterRecruiting

Rochester, New York
Site Public Contact, 585-275-5830

Carolinas Medical Center/Levine Cancer InstituteRecruiting

Charlotte, North Carolina
Site Public Contact, 800-804-9376

Duke University Medical CenterRecruiting

Durham, North Carolina
Site Public Contact, 888-275-3853

East Carolina UniversityRecruiting

Greenville, North Carolina
Site Public Contact, 252-744-1015, eubankss@ecu.edu

Mission HospitalRecruiting

Asheville, North Carolina
Site Public Contact, 828-213-7055, NCDV.ResearchRegulatory@HCAHealthcare.com

UNC Lineberger Comprehensive Cancer CenterRecruiting

Chapel Hill, North Carolina
Site Public Contact, 877-668-0683, cancerclinicaltrials@med.unc.edu

Wake Forest University Health SciencesRecruiting

Winston-Salem, North Carolina
Site Public Contact, 336-713-6771

Novant Health Presbyterian Medical CenterSuspended

Charlotte, North Carolina

Children's Hospital Medical Center of AkronRecruiting

Akron, Ohio
Site Public Contact, 330-543-3193

Cincinnati Children's Hospital Medical CenterRecruiting

Cincinnati, Ohio
Site Public Contact, 513-636-2799, cancer@cchmc.org

Cleveland Clinic FoundationRecruiting

Cleveland, Ohio
Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

Dayton Children's HospitalRecruiting

Dayton, Ohio
Site Public Contact, 800-228-4055

Nationwide Children's HospitalRecruiting

Columbus, Ohio
Site Public Contact, 614-072-2657, amy.yekisa@nationwidechildrens.org

ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalRecruiting

Toledo, Ohio
Site Public Contact, 419-824-1842

Rainbow Babies and Childrens HospitalRecruiting

Cleveland, Ohio
Site Public Contact, 216-844-5437

University of Oklahoma Health Sciences CenterRecruiting

Oklahoma City, Oklahoma
Site Public Contact, 405-271-8777, ou-clinical-trials@ouhsc.edu

Legacy Emanuel Children's HospitalRecruiting

Portland, Oregon
Site Public Contact, 503-413-2560

Oregon Health and Science UniversityRecruiting

Portland, Oregon
Site Public Contact, 503-494-1080, trials@ohsu.edu

Children's Hospital of PhiladelphiaRecruiting

Philadelphia, Pennsylvania
Site Public Contact, 267-425-5544, CancerTrials@email.chop.edu

Children's Hospital of Pittsburgh of UPMCRecruiting

Pittsburgh, Pennsylvania
Site Public Contact, 412-692-8570, jean.tersak@chp.edu

Geisinger Medical CenterRecruiting

Danville, Pennsylvania
Site Public Contact, 570-271-5251, HemonCCTrials@geisinger.edu

Lehigh Valley Hospital-Cedar CrestRecruiting

Allentown, Pennsylvania
Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org

Rhode Island HospitalRecruiting

Providence, Rhode Island
Site Public Contact, 401-444-1488

BI-LO Charities Children's Cancer CenterRecruiting

Greenville, South Carolina
Site Public Contact, 864-241-6251

Prisma Health Richland HospitalRecruiting

Columbia, South Carolina
Site Public Contact, 864-241-6251

Sanford USD Medical Center - Sioux FallsRecruiting

Sioux Falls, South Dakota
Site Public Contact, 605-312-3320, OncologyClinicalTrialsSF@SanfordHealth.org

East Tennessee Childrens HospitalRecruiting

Knoxville, Tennessee
Site Public Contact, 865-541-8266

Saint Jude Children's Research HospitalRecruiting

Memphis, Tennessee
Site Public Contact, 888-226-4343, referralinfo@stjude.org

The Children's Hospital at TriStar CentennialRecruiting

Nashville, Tennessee
Site Public Contact, 615-342-1919

Vanderbilt University/Ingram Cancer CenterRecruiting

Nashville, Tennessee
Site Public Contact, 800-811-8480

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting

Houston, Texas
Site Public Contact, 713-798-1354, burton@bcm.edu

Children's Hospital of San AntonioRecruiting

San Antonio, Texas
Site Public Contact, helpdesk@childrensoncologygroup.org

Cook Children's Medical CenterRecruiting

Fort Worth, Texas
Site Public Contact, 682-885-2103, CookChildrensResearch@cookchildrens.org

Covenant Children's HospitalRecruiting

Lubbock, Texas
Site Public Contact, helpdesk@childrensoncologygroup.org

Dell Children's Medical Center of Central TexasRecruiting

Austin, Texas
Site Public Contact, 512-628-1902, TXAUS-DL-SFCHemonc.research@ascension.org

Driscoll Children's HospitalRecruiting

Corpus Christi, Texas
Site Public Contact, 361-694-5311, Crystal.DeLosSantos@dchstx.org

El Paso Children's HospitalRecruiting

El Paso, Texas
Site Public Contact, 915-298-5444, ranjan.bista@ttuhsc.edu

M D Anderson Cancer CenterRecruiting

Houston, Texas
Site Public Contact, 877-632-6789, askmdanderson@mdanderson.org

Medical City Dallas HospitalRecruiting

Dallas, Texas
Site Public Contact, 972-566-5588

Methodist Children's Hospital of South TexasRecruiting

San Antonio, Texas
Site Public Contact, 210-575-6240, Vinod.GidvaniDiaz@hcahealthcare.com

Scott and White Memorial HospitalRecruiting

Temple, Texas
Site Public Contact, 254-724-5407

UMC Cancer Center / UMC Health SystemRecruiting

Lubbock, Texas
Site Public Contact, 806-775-8590

University of Texas Health Science Center at San AntonioRecruiting

San Antonio, Texas
Site Public Contact, 210-450-3800, phoresearchoffice@uthscsa.edu

UT Southwestern/Simmons Cancer Center-DallasRecruiting

Dallas, Texas
Site Public Contact, 214-648-7097, canceranswerline@UTSouthwestern.edu

Primary Children's HospitalRecruiting

Salt Lake City, Utah
Site Public Contact, 801-585-5270

University of Vermont and State Agricultural CollegeRecruiting

Burlington, Vermont
Site Public Contact, 802-656-8990, rpo@uvm.edu

Children's Hospital of The King's DaughtersRecruiting

Norfolk, Virginia
Site Public Contact, 757-668-7243, CCBDCresearch@chkd.org

Naval Medical Center - PortsmouthRecruiting

Portsmouth, Virginia
Site Public Contact, 757-953-5939

Virginia Commonwealth University/Massey Cancer CenterRecruiting

Richmond, Virginia
Site Public Contact, CTOclinops@vcu.edu

Madigan Army Medical CenterRecruiting

Tacoma, Washington
Site Public Contact, 253-968-6144, Melissa.a.forouhar.mil@mail.mil

Mary Bridge Children's Hospital and Health CenterRecruiting

Tacoma, Washington
Site Public Contact, 253-403-1461, research@multicare.org

Providence Sacred Heart Medical Center and Children's HospitalRecruiting

Spokane, Washington
Site Public Contact, 800-228-6618, HopeBeginsHere@providence.org

Seattle Children's HospitalRecruiting

Seattle, Washington
Site Public Contact, 866-987-2000

West Virginia University HealthcareActive, not recruiting

Morgantown, West Virginia

Children's Hospital of WisconsinRecruiting

Milwaukee, Wisconsin
Site Public Contact, 414-955-4727, MACCCTO@mcw.edu

University of Wisconsin Carbone Cancer CenterRecruiting

Madison, Wisconsin
Site Public Contact, 800-622-8922

ClinicalTrials.gov record


NCT03155620

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