Clinical Trial Goal
To find out:
- The highest dose of pembrolizumab that's safe to give with chemo
- If the combination of pembrolizumab and chemo is safe and works well to treat primary CNS DLBCL
You may be able to join this trial if you:
- Are 18 years old or older
- Have primary CNS DLBCL
- Do not have DLBCL outside of the CNS
- Have not been treated with any of the following (your doctor can tell you this):
- Anti PD-1
- Anti PD-L1
- Anti-PD-L2
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Methotrexate is a chemotherapy (chemo) drug that blocks growth of cancer cells.
Pembrolizumab is a checkpoint inhibitor that targets PD-1 on certain cells.
Rituximab is a monoclonal antibody that targets CD20 on certain cells.
Temozolomide is an alkylating agent that slows or stops the growth of cancer cells.
You’ll get treatment in cycles that last 2 weeks. In each cycle, you'll get:
Pembrolizumab is a checkpoint inhibitor that targets PD-1 on certain cells.
Rituximab is a monoclonal antibody that targets CD20 on certain cells.
Temozolomide is an alkylating agent that slows or stops the growth of cancer cells.
You’ll get treatment in cycles that last 2 weeks. In each cycle, you'll get:
- Methotrexate – Given as intravenous (IV) infusions. The dose you'll get depends on when you start the trial and how safe it has been
- Pembrolizumab – Given as IV infusions. The dose you'll get depends on when you start the trial and how safe it has been
- Rituximab – Given as IV infusions. The dose you'll get depends on when you start the trial and how safe it has been
- Temozolomide – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 3 years.
The Food and Drug Administration (FDA) has approved all of the drugs used in this trial.
Contacts
Lakshmi Nayak, MD, 617-632-2166, Lakshmi_Nayak@DFCI.HARVARD.EDU
DFCI Clinical Trials Hotline, 877-338-7425
Locations
Brigham and Women's HospitalRECRUITING
Boston, Massachusetts
Lakshmi Nayak, MD, 617-632-2166, Lakshmi_Nayak@DFCI.HARVARD.EDU
Dana Farber Cancer InstituteRECRUITING
Boston, Massachusetts
Lakshmi Nayak, MD, 617-632-2166, Lakshmi_Nayak@DFCI.HARVARD.EDU
Sponsors
collaborator: Merck Sharp & Dohme LLC, lead: Dana-Farber Cancer Institute
