Clinical Trial Goal
To find out if NK cells are safe and work well to treat leukemia or lymphoma and to prevent graft-versus-host disease (GVHD) after cord blood transplant
You may be able to join this trial if you:
- Are 15 – 80 years old
- Have one of the following diseases:
- Acute lymphocytic leukemia (ALL)
- Acute myeloid leukemia (AML)
- Chronic lymphocytic leukemia (CLL)
- Chronic myeloid leukemia (CML)
- Hodgkin lymphoma
- Multiple myeloma
- Myelodysplastic syndrome (MDS)
- Non-Hodgkin lymphoma (NHL)
- Small lymphocytic lymphoma (SLL)
- Are not able to get standard treatment
- Plan to have an allogeneic (cells from a donor) blood or marrow transplant (BMT)
- Do not have a matched, related donor for BMT
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
This trial is being done at MD Anderson Cancer Center in Houston, Texas.
Before transplant, you’ll get standard drugs and possibly total body irradiation (TBI) to prepare your body for transplant day.
On transplant day, blood-forming cells from the donated umbilical cord blood unit are given to you through an IV infusion.
After transplant, the clinical trial doctors will test your blood to see how the treatment is working. Based on this test, you may get either:
Before transplant, you’ll get standard drugs and possibly total body irradiation (TBI) to prepare your body for transplant day.
On transplant day, blood-forming cells from the donated umbilical cord blood unit are given to you through an IV infusion.
After transplant, the clinical trial doctors will test your blood to see how the treatment is working. Based on this test, you may get either:
- NK cells and standard care. NK cells are blood cells and part of the immune system. You’ll get them 2 times by IV infusion, between 1 and 6 months after transplant. Doctors separate the NK cells from the cord blood unit before your transplant.
- Standard care only
You’ll stay in the hospital for at least 2 – 4 weeks after transplant. When you leave the hospital, you will have to stay in the Houston area for about 3 months and see the clinical trial doctors 2 times each week.
You’ll be in the trial for 2 years, but the clinical trial doctors will continue to check you each year after that. You'll have bone marrow biopsies to see how the treatment is working.
The Food and Drug Administration (FDA) has approved the drugs in this trial for blood cancers or for use in transplant. Giving NK cells after transplant is new and unproven.
Locations
M D Anderson Cancer CenterRECRUITING
Houston, Texas
Sponsors
collaborator: National Cancer Institute (NCI), lead: M.D. Anderson Cancer Center
