Clinical Trial Goal
To find out:
- The highest dose of LMY-920 that's safe to give
- If LMY-920 is safe and works well to treat CLL or SLL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have CLL or SLL that has relapsed or is refractory
- Do not have lymphoma in your brain or spinal cord
- Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT)
- Do not have active graft-versus-host-disease (GVHD)
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
Cyclophosphamide and fludarabine are chemotherapy (chemo) drugs that block the growth of cancer cells.
LMY-920 is a type of CAR T-cell therapy that targets BAFF on certain cells.
Obinutuzumab is a monoclonal antibody that targets CD20 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get treatment 3 standard drugs:
Cyclophosphamide and fludarabine are chemotherapy (chemo) drugs that block the growth of cancer cells.
LMY-920 is a type of CAR T-cell therapy that targets BAFF on certain cells.
Obinutuzumab is a monoclonal antibody that targets CD20 on certain cells.
To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
Before the CAR T-cell infusion, you’ll get treatment 3 standard drugs:
- Cyclophosphamide – Given as intravenous (IV) infusions. The dose you'll get depends on when you start the trial and how safe it has been
- Fludarabine – Given as intravenous (IV) infusions. The dose you'll get depends on when you start the trial and how safe it has been
- Obinutuzumab – Given as intravenous (IV) infusions. The dose you'll get depends on when you start the trial and how safe it has been
Then, the CAR T cells are given to you through an IV infusion. The dose of cells you’ll get depends on when you start the trial and how safe it has been.
The clinical trial doctors will watch you closely over 1 year. You'll have biopsies and/or scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.
The Food and Drug Administration (FDA) has not yet approved LMY-920.
Watch a video about CAR T-Cell Therapy
Locations
Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer InstituteRECRUITING
Cleveland, Ohio
Paolo Caimi, MD
Sponsors
collaborator: The Leukemia and Lymphoma Society, lead: Paolo Caimi, MD
