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Viral specific T cells (VSTs), posoleucel, to treat adenovirus infection after an allogeneic (cells from a donor) blood or marrow transplant (BMT) in children and adults

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1 and older

Phase 3

8 Locations

NCT05179057

Clinical Trial Goal


To find out if posoleucel is safe and works well to treat adenovirus infection after allogeneic BMT in children and adults

You may be able to join this trial if you:


  • Have an adenovirus (AdV) infection
  • Had an allogeneic BMT
  • Do not have graft-versus-host disease (GVHD) that doctors consider grade 2 or higher
  • Are not being treated with high-dose steroids. Your doctor can tell you this
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


Posoleucel is made from VSTs. VSTs are a type of immune cell that know how to find and destroy viruses. In this trial, VSTs are previously collected from donors.

In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Group 1 – Posoleucel
Group 2 Placebo  

Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.  

You'll get:
  • Posoleucel – (Group 1 only) – Given as an intravenous (IV) infusion
  • Placebo – (Group 2 only) – Given as an IV infusion with no medicine in it 

The clinical trial doctors will check your health for 1 month.

The Food and Drug Administration (FDA) not yet approved posoleucel. 

Contacts


Chrissy Pelland, +1 833-409-2281, ClinicalTrials@allovir.com

Locations

University of California, San Diego - Rady Children's HospitalRecruiting

San Diego, California

Children's Hospital Colorado - Center for Cancer and Blood DisordersRecruiting

Aurora, Colorado

Children's National Medical CenterRecruiting

Washington, District of Columbia

University of Florida (UF) - GainesvilleRecruiting

Gainesville, Florida

Ann and Robert H. Lurie Children's Hospital of ChicagoRecruiting

Chicago, Illinois

Dana-Farber Cancer InstituteRecruiting

Boston, Massachusetts

University of MinnesotaRecruiting

Minneapolis, Minnesota

Hackensack University Medical CenterRecruiting

Hackensack, New Jersey

ClinicalTrials.gov record


NCT05179057

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