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A drug, QXL138AM, to treat multiple myeloma that has come back (relapsed) or not gotten better with treatment (refractory)

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18 and older

Phase 1

10 Locations

NCT06582017

Clinical Trial Goal


To find out:
  • The highest dose of QXL138AM that's safe to give
  • If QXL138AM is safe and works well to treat multiple myeloma that has relapsed or is refractory

You may be able to join this trial if you:


  • Are 18 years old or older
  • Have multiple myeloma that has relapsed or is refractory
  • Have been treated with all of the following (your doctor can tell you this):
    • A drug that targets CD38
    • An IMiD
    • A Proteosome inhibitor
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


QXL138AM is an interferon alpha 2 (IFNa2) masked immunocytokine (MIC) that is fused to an antibody that targets CD138.

You’ll get:
  • QXL138AM – Given as intravenous (IV) infusions 1 time every 2 weeks

You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for 3.5 years. 

The Food and Drug Administration (FDA) has not yet approved QXL138AM. 

Contacts


David Stover, PhD, 818-926-3428, David.Stover@nammirx.com

Locations

Cedars-Sanai Medical CenterRECRUITING

Los Angeles, California
Alain Mita, MD

Cedars-Sanai Medical Center - Samuel Oschin Comprehensive CancerRECRUITING

Los Angeles, California
Kamya Sankar, MD, 248-802-2041, kamya.sankar@cshs.org

Hoag Memorial Hospital PresbyterianRECRUITING

Newport, California
Benjamin Goldenson, MD, 949-764-4060, Benjamin.Goldenson@Hoag.org

University of Southern CaliforniaRECRUITING

Los Angeles, California
Anthony El-Khoueiry, MD, 323-865-3962, elkhouei@med.usc.edu

Sarah Cannon Research Institute - Denver DDURECRUITING

Denver, Colorado
Jason T Henry, MD, 720-754-2610, Jason.Henry2@SarahCannon.com

Emory University - Winship Cancer InstituteRECRUITING

Atlanta, Georgia
Fatemeh Ardeshir, MD, 404-778-0202, fatemeh.ardeshir.larijani@emory.edu

New York Cancer & Blood SpecialistsRECRUITING

New York, New York
Richard Zuniga, MD, 613-675-5075, zunigaresearch@nycancer.com

University of Rochester - Wilmot Cancer InstituteRECRUITING

Rochester, New York
Brea Lipe, MD, 585-276-6302, brea_lipe@urmc.rochester.edu

START San AntonioRECRUITING

San Antonio, Texas
Drew Drasco, MD, 210-593-5258, drasco@startsa.com

Froedtert Hospital & the Medical College of WisconsinRECRUITING

Milwaukee, Wisconsin
Binod Dhakal, MD

ClinicalTrials.gov record


NCT06582017. First posted on 9/3/24

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