Clinical Trial Goal
To find out:
- The highest dose of seclidemstat that’s safe to give with azacitidine
- If the combination of azacitidine and seclidemstat is safe and works well to treat CMML or MDS
You may be able to join this trial if you:
- Are 18 years old or older
- Have CMML or MDS
- Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 6 months
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Azacitidine is a drug that blocks the growth of cancer cells.
Seclidemstat is a small molecule inhibitor that blocks LSD1 in certain cells.
You’ll get treatment in cycles that last a month. In each cycle, you'll get:
Seclidemstat is a small molecule inhibitor that blocks LSD1 in certain cells.
You’ll get treatment in cycles that last a month. In each cycle, you'll get:
- Azacitidine – Given as intravenous (IV) infusions or a shot under your skin 7 times
- Seclidemstat – Given as a pill that you take by mouth 1 or 2 times each day. The dose you'll get depends on when you start the trial and how safe it has been
You may continue treatment for as long as the clinical trial doctors think it’s best for your health. You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for up to 1 year.
The Food and Drug Administration (FDA) has approved azacitidine to treat CMML or MDS. The FDA has not yet approved seclidemstat.
Locations
M D Anderson Cancer CenterRECRUITING
Houston, Texas
Guillermo M. Bravo, M D, 713-794-3604
Sponsors
lead: M.D. Anderson Cancer Center
