Comprehensive ablative bridging irradiation (CABI) before CAR T cells (Yascarta) to treat diffuse large B-cell lymphoma (DLBCL) that has come back (relapsed) or not gotten better with treatment (refractory)

To find out if CABI before Yascarta is safe and works well to treat DLBCL that has relapsed or is refractory

Comprehensive ablative bridging irradiation (CABI) is a type of therapy that provides high-dose radiation to target and destroy cancer cells. 
CAR stands for chimeric antigen receptors and T stands for T cells, a type of immune cell. This treatment helps your own immune system find and destroy cancer cells.
Yascarta is a type of CAR T-cell therapy that targets CD19 on certain cells. 

To make CAR T cells, T cells are collected from you by apheresis. Apheresis is a process to collect cells from the bloodstream using a needle similar to when you donate blood. The T cells are genetically modified to grow special proteins called CARs. CARs help T cells find the cancer cells. The CAR T cells are grown in a lab until there are millions of them. Then, they’re given back to you to find and destroy the cancer cells.
 
Before the CAR T-cell infusion, you’ll get:

Next, you'll get chemotherapy (chemo) with standard drugs.

Then, the CAR T cells are given to you through an IV infusion.

The clinical trial doctors will watch you closely over 1 year. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 15 years.

The Food and Drug Administration (FDA) has approved all of the drugs used in this trial. Using CABI before CAR T-cell therapy to treat DLBCL that has relapsed or is refractory is new and unproven. 

Watch a video about CAR T-Cell Therapy