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A drug, INCA036978, alone and in combination with standard treatment, to treat myeloproliferative neoplasm (MPN) 

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18 and older

Phase 1

23 Locations

NCT07441694

Clinical Trial Goal


To find out:
  • The highest dose of INCA036978 that's safe to give
  • If INCA036978 is safe and works well to treat MPN

You may be able to join this trial if you:


  • Are 18 years old or older
  • Have MPN. Some examples include:
    • Essential thrombocythemia
    • Polycythemia vera 
    • Primary myelofibrosis
  • Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) 
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


INCA036978 is a monoclonal antibody that doctors believe can target and treat MPN. 

You’ll get:
  • INCA036978  – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been

You'll have blood tests and/or biopsies to see how well the treatment is working. The clinical trial doctors will check your health for 2 years.

The Food and Drug Administration (FDA) has not yet approved INCA036978. 

Contacts


Incyte Corporation Call Center (US), 1.855.463.3463, medinfo@incyte.com

Incyte Corporation Call Center (ex-US), +800 00027423, eumedinfo@incyte.com

Locations

University of Alabama At BirminghamNOT_YET_RECRUITING

Birmingham, Alabama

City of Hope-Lennar Foundation Cancer CenterNOT_YET_RECRUITING

Irvine, California

UCLA Medical Hematology & OncologyNOT_YET_RECRUITING

Los Angeles, California

Usc Norris Comprehensive Cancer CenterNOT_YET_RECRUITING

Los Angeles, California

Yale Cancer CenterNOT_YET_RECRUITING

New Haven, Connecticut

Moffitt Cancer CenterNOT_YET_RECRUITING

Tampa, Florida

University of MiamiNOT_YET_RECRUITING

Miami, Florida

Winship Cancer Institute of Emory UniversityRECRUITING

Atlanta, Georgia

John Hopkins HospitalNOT_YET_RECRUITING

Baltimore, Maryland

Massachusetts General HospitalNOT_YET_RECRUITING

Boston, Massachusetts

Washington University School of MedicineNOT_YET_RECRUITING

St Louis, Missouri

Memorial Sloan Kettering Cancer CenterNOT_YET_RECRUITING

New York, New York

Mount Sinai School of MedicineNOT_YET_RECRUITING

New York, New York

Weill Cornell MedicineNOT_YET_RECRUITING

New York, New York

Duke University Medical Center, Department of Hematologic Malignancies and Cellular TherapyNOT_YET_RECRUITING

Durham, North Carolina

Levine Cancer InstituteNOT_YET_RECRUITING

Charlotte, North Carolina

University of North Carolina At Chapel HillNOT_YET_RECRUITING

Chapel Hill, North Carolina

Cleveland ClinicNOT_YET_RECRUITING

Cleveland, Ohio

Ohio State UniversityRECRUITING

Columbus, Ohio

Tristar Bmt/TctoRECRUITING

Nashville, Tennessee

University of Texas M. D. Anderson Cancer CenterNOT_YET_RECRUITING

Houston, Texas

Huntsman Cancer InstituteNOT_YET_RECRUITING

Salt Lake City, Utah

Medical College of WisconsinNOT_YET_RECRUITING

Milwaukee, Wisconsin

ClinicalTrials.gov record


NCT07441694. First posted on Mar 2

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