Clinical Trial Goal
To find out:
- The highest dose of NMS-03597812 that's safe to give
- If NMS-03597812 is safe and works well to treat AML that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years old or older
- Have AML that has relapsed or is refractory
- Have cancer cells with mutation/marker TP53 (TP53+). Your doctor can tell you this
- Do not have acute promyelocytic leukemia
- Have not had an autologous (your own cells) or allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
- Do not have graft-versus-host-disease (GVHD)
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
NMS-03597812 is a small molecule inhibitor that blocks PERK in certain cells.
You’ll get treatment in cycles that last 1 month. In each cycle, you'll get:
You’ll get treatment in cycles that last 1 month. In each cycle, you'll get:
- NMS-03597812 – A pill that you take by mouth 1 time each day
You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for up to about 1.5 years.
The Food and Drug Administration (FDA) has not yet approved NMS-03597812.
Locations
Sponsors
lead: Nerviano Medical Sciences
