Featured Trial
Clinical Trial Goal
To find out if posoleucel is safe and works well to prevent viral infections after allogeneic BMT in children and adults
You may be able to join this trial if you:
- Are 1 year old or older
- Have an infection with one of the following:
- Adenovirus (AdV)
- BK virus (BKV)
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV)
- Human herpes virus-6 (HHV-6)
- JC virus (JCV)
- Had an allogeneic BMT in the last 6 weeks
- Have a posoleucel product that is a match to you. Your doctor and the clinical trial doctors can tell you this
- Do not have graft-versus-host disease (GVHD) that doctors consider grade 2 or higher
- Are not being treated with high-dose steroids. Your doctor can tell you this
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Posoleucel is made from VSTs. VSTs are a type of immune cell that know how to find and destroy viruses. In this trial, VSTs are previously collected from donors.
Everyone in the trial will get standard treatment if they develop an infection.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Group 1 – Posoleucel
Group 2 – Placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You'll get:
Everyone in the trial will get standard treatment if they develop an infection.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Group 1 – Posoleucel
Group 2 – Placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You'll get:
- Posoleucel – (Group 1 only) – Given as an intravenous (IV) infusion 7 times in 3 months
- Placebo – (Group 2 only) – Given as an IV infusion with no medicine in it 7 times in 3 months
The clinical trial doctors will check your health for about 6 months.
The Food and Drug Administration (FDA) not yet approved posoleucel.
Locations
Sponsors
lead: AlloVir
