Clinical Trial Goal
To find out:
- The highest dose of CCS1477 that's safe to give
- If CCS1477 is safe and works well to treat AML, multiple myeloma, high-risk MDS and NHL that has relapsed or is refractory
You may be able to join this trial if you:
- Are 18 years or older
- Have one of the following that has relapsed or is refractory:
- AML
- Multiple myeloma
- MDS that doctors consider high-risk
- NHL, some examples include:
- Diffuse large B-cell lymphoma (DLBCL)
Follicular lymphoma
Indolent lymphoma
Mantle cell lymphoma (MCL)
Marginal zone lymphoma (MZL)
Mediastinal large B-cell lymphoma
Richter's transformation
Small lymphocytic lymphoma (SLL)
- Diffuse large B-cell lymphoma (DLBCL)
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Azacitidine and pomalidomide are drugs that block the growth of cancer cells.
CCS1477 is a small molecule inhibitor that blocks p300 and CBP in certain cells
Dexamethasone is a drug that reduces inflammation.
Venetoclax is a small molecule inhibitor that blocks BCL2 in certain cells.
You’ll get:
CCS1477 is a small molecule inhibitor that blocks p300 and CBP in certain cells
Dexamethasone is a drug that reduces inflammation.
Venetoclax is a small molecule inhibitor that blocks BCL2 in certain cells.
You’ll get:
- Azacitidine – Given as a shot under your skin. The dose you'll get depends on when you start the trial and how safe it has been
- CCS1477 – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
- Dexamethasone – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
- Pomalidomide – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
- Venetoclax – A pill that you take by mouth. The dose you'll get depends on when you start the trial and how safe it has been
You may continue treatment for as long as the doctors think is best for your health. You'll have biopsies and/or scans to see how well the treatment is working. The clinical trial doctors will check your health for up tp 1 year.
The Food and Drug Administration (FDA) has approved azacitidine, dexamethasone and venetoclax. The FDA has not yet approved CCS1477.
Contacts
Tomasz Knurowski, PhD, 07882871299, Tomasz.Knurowski@cellcentric.com
Karen Clegg, MD, MFPM, Karen.Clegg@cellcentric.com
Locations
Sponsors
lead: CellCentric Ltd.
