Featured Trial
Clinical Trial Goal
To find out if posoleucel is safe and works well to treat virus-associated HC after allogeneic BMT in children and adults
You may be able to join this trial if you:
- Are 1 years old or older
- Have virus-associated HC
- Had an allogeneic BMT in the last year
- Have a posoleucel product that is a match to you. Your doctor and the clinical trial doctors can tell you this
- Do not have graft-versus-host disease (GVHD) that doctors consider grade 2 or higher
- Are not being treated with high-dose steroids. Your doctor can tell you this
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Posoleucel is made from VSTs. VSTs are a type of immune cell that know how to find and destroy viruses. In this trial, VSTs are previously collected from donors. Doctors think posoleucel can treat HC when it’s associated with adenovirus (AdV), BK virus (BKV), cytomegalovirus (CMV), Epstein Barr virus (EBV), human herpesvirus 6 (HHV-6) or JC virus (JCV).
Everyone in this trial will get standard treatment if they get an infection.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Group 1 – Posoleucel
Group 2 – Placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You'll get:
Everyone in this trial will get standard treatment if they get an infection.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you and the clinical trial doctors won’t know which group you’re in until after the trial is finished:
Group 1 – Posoleucel
Group 2 – Placebo
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You'll get:
- Posoleucel – (Group 1 only) – Given as an intravenous (IV) infusion
- Placebo – (Group 2 only) – Given as an IV infusion with no medicine in it
The clinical trial doctors will check your health for 6 months.
The Food and Drug Administration (FDA) not yet approved posoleucel
Locations
Sponsors
lead: AlloVir
