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A drug, OBI-3424, to treat T-cell acute lymphoblastic leukemia (T-ALL) that has come back (relapsed) or has not gotten better with treatment (refractory)

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12 and older

Phase 1, Phase 2

163 Locations

NCT04315324

Clinical Trial Goal


To find out if OBI-3424 is safe and works well to treat T-ALL that has relapsed or is refractory

You may be able to join this trial if you:


  • Are 18 years old and older
  • Have T-ALL that has relapsed or is refractory
  • Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
  • Agree to have other standard tests done to see if you can be in the clinical trial 

Trial Details


OBI-3424 is a chemotherapy (chemo) drug that blocks the growth of cancer cells when exposed to an enzyme called AKR1C3.

You’ll get treatment in cycles that last 3 weeks. In each cycle, you'll get: 
  • OBI-3424 – Given as intravenous (IV) infusions 1 time each week for the first 2 weeks of each cycle. Each infusion takes 30 minutes

You may continue treatment for up to about 1 year. You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for up to 5 years.

The Food and Drug Administration (FDA) has not yet approved OBI-3424. 

Locations

University of Alabama at Birmingham Cancer CenterACTIVE_NOT_RECRUITING

Birmingham, Alabama

Kingman Regional Medical CenterRECRUITING

Kingman, Arizona
Site Public Contact, 702-384-0013, research@sncrf.org

Arkansas Children's HospitalRECRUITING

Little Rock, Arkansas
Site Public Contact, 501-364-7373

Children's Hospital of Orange CountyRECRUITING

Orange, California
Site Public Contact, 714-509-8646, oncresearch@choc.org

City of Hope Comprehensive Cancer CenterRECRUITING

Duarte, California
Site Public Contact, 800-826-4673, becomingapatient@coh.org

Loma Linda University Medical CenterRECRUITING

Loma Linda, California
Site Public Contact, 909-558-4050

PCR OncologyRECRUITING

Arroyo Grande, California
Site Public Contact, 702-384-0013, research@sncrf.org

Children's Hospital ColoradoRECRUITING

Aurora, Colorado
Site Public Contact, 303-764-5056, josh.b.gordon@nsmtp.kp.org

Alfred I duPont Hospital for ChildrenRECRUITING

Wilmington, Delaware
Site Public Contact, 302-651-5572, Allison.bruce@nemours.org

Golisano Children's Hospital of Southwest FloridaRECRUITING

Fort Myers, Florida
Site Public Contact, 239-343-5333, molly.arnstrom@leehealth.org

Johns Hopkins All Children's HospitalRECRUITING

St. Petersburg, Florida
Site Public Contact, 727-767-4784, Ashley.Repp@jhmi.edu

Memorial Regional Hospital/Joe DiMaggio Children's HospitalRECRUITING

Hollywood, Florida
Site Public Contact, 954-265-1847, OHR@mhs.net

Augusta University Medical CenterRECRUITING

Augusta, Georgia
Site Public Contact, 706-721-2388, ga_cares@augusta.edu

Children's Healthcare of Atlanta - Arthur M Blank HospitalRECRUITING

Atlanta, Georgia
Site Public Contact, 404-785-0232, Olivia.Floyd@choa.org

Emory University Hospital/Winship Cancer InstituteRECRUITING

Atlanta, Georgia
Site Public Contact, 404-778-1868

Loyola Center for Health at Burr RidgeACTIVE_NOT_RECRUITING

Burr Ridge, Illinois

Loyola Medicine Homer GlenACTIVE_NOT_RECRUITING

Homer Glen, Illinois

Loyola University Medical CenterACTIVE_NOT_RECRUITING

Maywood, Illinois

Marjorie Weinberg Cancer Center at Loyola-GottliebACTIVE_NOT_RECRUITING

Melrose Park, Illinois

Northwestern Medicine Lake Forest HospitalACTIVE_NOT_RECRUITING

Lake Forest, Illinois

UC Comprehensive Cancer Center at Silver CrossACTIVE_NOT_RECRUITING

New Lenox, Illinois

University of Chicago Comprehensive Cancer CenterACTIVE_NOT_RECRUITING

Chicago, Illinois

University of Chicago Medicine-Orland ParkACTIVE_NOT_RECRUITING

Orland Park, Illinois

Lurie Children's Hospital-ChicagoRECRUITING

Chicago, Illinois
Site Public Contact, 773-880-4562

Northwestern UniversityRECRUITING

Chicago, Illinois
Site Public Contact, 312-695-1301, cancer@northwestern.edu

Southern Illinois University School of MedicineRECRUITING

Springfield, Illinois
Site Public Contact, 217-545-7929

University of IllinoisRECRUITING

Chicago, Illinois
Site Public Contact, 312-355-3046

Mary Greeley Medical CenterRECRUITING

Ames, Iowa
Site Public Contact, 515-956-4132

McFarland Clinic - AmesRECRUITING

Ames, Iowa
Site Public Contact, 515-239-4734, ksoder@mcfarlandclinic.com

McFarland Clinic - BooneRECRUITING

Boone, Iowa
Site Public Contact, 515-956-4132

McFarland Clinic - JeffersonRECRUITING

Jefferson, Iowa
Site Public Contact, 515-956-4132

McFarland Clinic - MarshalltownRECRUITING

Marshalltown, Iowa
Site Public Contact, 515-956-4132

McFarland Clinic - Trinity Cancer CenterRECRUITING

Fort Dodge, Iowa
Site Public Contact, 515-956-4132

Norton Children's HospitalRECRUITING

Louisville, Kentucky
Site Public Contact, 502-629-5500, CancerResource@nortonhealthcare.org

LSU Health Baton Rouge-North ClinicRECRUITING

Baton Rouge, Louisiana
Site Public Contact, 225-765-7659, research@ololrmc.com

Our Lady of the Lake Physician GroupRECRUITING

Baton Rouge, Louisiana
Site Public Contact, 225-765-7659, research@ololrmc.com

Johns Hopkins University/Sidney Kimmel Cancer CenterRECRUITING

Baltimore, Maryland
Site Public Contact, 410-955-8804, jhcccro@jhmi.edu

Wayne State University/Karmanos Cancer InstituteACTIVE_NOT_RECRUITING

Detroit, Michigan

Weisberg Cancer Treatment CenterACTIVE_NOT_RECRUITING

Farmington Hills, Michigan

Beacon KalamazooRECRUITING

Kalamazoo, Michigan
Site Public Contact, 574-647-7370

Beacon Kalamazoo Cancer CenterRECRUITING

Kalamazoo, Michigan
Site Public Contact, 574-647-7370

Bronson Battle CreekRECRUITING

Battle Creek, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Bronson Methodist HospitalRECRUITING

Kalamazoo, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Cancer and Hematology Centers of Western Michigan - Norton ShoresRECRUITING

Norton Shores, Michigan
Site Public Contact, 616-391-1230, connie.szczepanek@crcwm.org

Corewell Health Grand Rapids Hospitals - Butterworth HospitalRECRUITING

Grand Rapids, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalRECRUITING

Grand Rapids, Michigan
Site Public Contact, 616-267-1925, crcwm-regulatory@crcwm.org

Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterRECRUITING

Saint Joseph, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Corewell Health Lakeland Hospitals - Niles HospitalRECRUITING

Niles, Michigan
Site Public Contact, 616-391-1230

Corewell Health Lakeland Hospitals - Saint Joseph HospitalRECRUITING

Saint Joseph, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Corewell Health Reed City HospitalRECRUITING

Reed City, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Munson Medical CenterRECRUITING

Traverse City, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Trinity Health Grand Rapids HospitalRECRUITING

Grand Rapids, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Trinity Health Muskegon HospitalRECRUITING

Muskegon, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

University of Michigan Health - WestRECRUITING

Wyoming, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

West Michigan Cancer CenterRECRUITING

Kalamazoo, Michigan
Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

Abbott-Northwestern HospitalACTIVE_NOT_RECRUITING

Minneapolis, Minnesota

Cambridge Medical CenterACTIVE_NOT_RECRUITING

Cambridge, Minnesota

Fairview Clinics and Surgery Center Maple GroveACTIVE_NOT_RECRUITING

Maple Grove, Minnesota

Fairview Lakes Medical CenterACTIVE_NOT_RECRUITING

Wyoming, Minnesota

Fairview Northland Medical CenterACTIVE_NOT_RECRUITING

Princeton, Minnesota

Fairview Ridges HospitalACTIVE_NOT_RECRUITING

Burnsville, Minnesota

Fairview Southdale HospitalACTIVE_NOT_RECRUITING

Edina, Minnesota

Health Partners IncACTIVE_NOT_RECRUITING

Minneapolis, Minnesota

Hennepin County Medical CenterACTIVE_NOT_RECRUITING

Minneapolis, Minnesota

Lakeview HospitalACTIVE_NOT_RECRUITING

Stillwater, Minnesota

Mercy HospitalACTIVE_NOT_RECRUITING

Coon Rapids, Minnesota

Minnesota Oncology - BurnsvilleACTIVE_NOT_RECRUITING

Burnsville, Minnesota

Minnesota Oncology Hematology PA-MaplewoodACTIVE_NOT_RECRUITING

Maplewood, Minnesota

Minnesota Oncology Hematology PA-WoodburyACTIVE_NOT_RECRUITING

Woodbury, Minnesota

Monticello Cancer CenterACTIVE_NOT_RECRUITING

Monticello, Minnesota

New Ulm Medical CenterACTIVE_NOT_RECRUITING

New Ulm, Minnesota

North Memorial Medical Health CenterACTIVE_NOT_RECRUITING

Robbinsdale, Minnesota

Park Nicollet Clinic - Saint Louis ParkACTIVE_NOT_RECRUITING

Saint Louis Park, Minnesota

Regions HospitalACTIVE_NOT_RECRUITING

Saint Paul, Minnesota

Rice Memorial HospitalACTIVE_NOT_RECRUITING

Willmar, Minnesota

Ridgeview Medical CenterACTIVE_NOT_RECRUITING

Waconia, Minnesota

Saint Francis Regional Medical CenterACTIVE_NOT_RECRUITING

Shakopee, Minnesota

Saint John's Hospital - HealtheastACTIVE_NOT_RECRUITING

Maplewood, Minnesota

United HospitalACTIVE_NOT_RECRUITING

Saint Paul, Minnesota

Unity HospitalACTIVE_NOT_RECRUITING

Fridley, Minnesota

University of Minnesota/Masonic Cancer CenterRECRUITING

Minneapolis, Minnesota
Site Public Contact, 612-624-2620

Children's Mercy Hospitals and ClinicsRECRUITING

Kansas City, Missouri
Site Public Contact, 816-302-6808, rryan@cmh.edu

Children's Hospital and Medical Center of OmahaRECRUITING

Omaha, Nebraska
Site Public Contact, 402-955-3949

University of Nebraska Medical CenterRECRUITING

Omaha, Nebraska
Site Public Contact, 402-559-6941, unmcrsa@unmc.edu

Alliance for Childhood Diseases/Cure 4 the Kids FoundationRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Ann M Wierman MD LTDRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Cancer and Blood Specialists-HendersonRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Carson Tahoe Regional Medical CenterRECRUITING

Carson City, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of NevadaRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada - Central ValleyRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada - HendersonRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada-Horizon RidgeRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada - NorthwestRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada-Southeast HendersonRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada-SummerlinRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Comprehensive Cancer Centers of Nevada - Town CenterRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

GenesisCare USA - Fort ApacheRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

GenesisCare USA - HendersonRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

GenesisCare USA - Las VegasRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

GenesisCare USA - Vegas TenayaRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Hope Cancer Care of NevadaRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Hope Cancer Care of Nevada-PahrumpRECRUITING

Pahrump, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Las Vegas Prostate Cancer CenterRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Las Vegas Urology - Cathedral RockRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Las Vegas Urology - Green ValleyRECRUITING

Henderson, Nevada
Site Public Contact, research@sncrf.org

Las Vegas Urology - PebbleRECRUITING

Henderson, Nevada
Site Public Contact, research@sncrf.org

Las Vegas Urology - PecosRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Las Vegas Urology - Smoke RanchRECRUITING

Las Vegas, Nevada
Site Public Contact, research@smcrf.org

Las Vegas Urology - SunsetRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

OptumCare Cancer Care at CharlestonRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

OptumCare Cancer Care at Fort ApacheRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

OptumCare Cancer Care at MountainViewRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

OptumCare Cancer Care at Seven HillsRECRUITING

Henderson, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Radiation Oncology AssociatesRECRUITING

Reno, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Radiation Oncology Centers of Nevada CentralRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Radiation Oncology Centers of Nevada SoutheastRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Renown Regional Medical CenterRECRUITING

Reno, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Saint Mary's Regional Medical CenterRECRUITING

Reno, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Summerlin Hospital Medical CenterRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Sunrise Hospital and Medical CenterRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

University Cancer CenterRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

University Medical Center of Southern NevadaRECRUITING

Las Vegas, Nevada
Site Public Contact, 702-384-0013, research@sncrf.org

Urology Specialists of Nevada - CentralRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Urology Specialists of Nevada - Green ValleyRECRUITING

Henderson, Nevada
Site Public Contact, research@sncrf.org

Urology Specialists of Nevada - NorthwestRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Urology Specialists of Nevada - SouthwestRECRUITING

Las Vegas, Nevada
Site Public Contact, research@sncrf.org

Desert West SurgerySUSPENDED

Las Vegas, Nevada

HealthCare Partners Medical Group Oncology/Hematology-Centennial HillsSUSPENDED

Las Vegas, Nevada

HealthCare Partners Medical Group Oncology/Hematology-Maryland ParkwaySUSPENDED

Las Vegas, Nevada

HealthCare Partners Medical Group Oncology/Hematology-San MartinSUSPENDED

Las Vegas, Nevada

HealthCare Partners Medical Group Oncology/Hematology-TenayaSUSPENDED

Las Vegas, Nevada

Las Vegas Cancer Center-HendersonSUSPENDED

Henderson, Nevada

Las Vegas Cancer Center-Medical CenterSUSPENDED

Las Vegas, Nevada

University of New Mexico Cancer CenterRECRUITING

Albuquerque, New Mexico
Site Public Contact, 505-925-0348, HSC-ClinicalTrialInfo@salud.unm.edu

Roswell Park Cancer InstituteACTIVE_NOT_RECRUITING

Buffalo, New York

University of RochesterRECRUITING

Rochester, New York
Site Public Contact, 585-275-5830

Duke University Medical CenterRECRUITING

Durham, North Carolina
Site Public Contact, 888-275-3853

Cincinnati Children's Hospital Medical CenterRECRUITING

Cincinnati, Ohio
Site Public Contact, 513-636-2799, cancer@cchmc.org

Cleveland Clinic FoundationRECRUITING

Cleveland, Ohio
Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

University of Cincinnati Cancer Center-UC Medical CenterRECRUITING

Cincinnati, Ohio
Site Public Contact, 513-584-7698, cancer@uchealth.com

University of Cincinnati Cancer Center-West ChesterSUSPENDED

West Chester, Ohio

Oregon Health and Science UniversityACTIVE_NOT_RECRUITING

Portland, Oregon

Children's Hospital of PhiladelphiaRECRUITING

Philadelphia, Pennsylvania
Site Public Contact, 267-425-5544, CancerTrials@email.chop.edu

Children's Hospital of Pittsburgh of UPMCRECRUITING

Pittsburgh, Pennsylvania
Site Public Contact, 412-692-8570, jean.tersak@chp.edu

Rhode Island HospitalRECRUITING

Providence, Rhode Island
Site Public Contact, 401-444-1488

Prisma Health Richland HospitalRECRUITING

Columbia, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

The Children's Hospital at TriStar CentennialRECRUITING

Nashville, Tennessee
Site Public Contact, 615-342-1919

Dell Children's Medical Center of Central TexasRECRUITING

Austin, Texas
Site Public Contact, 512-628-1902, TXAUS-DL-SFCHemonc.research@ascension.org

El Paso Children's HospitalRECRUITING

El Paso, Texas
Site Public Contact, 915-298-5444, ranjan.bista@ttuhsc.edu

Methodist Children's Hospital of South TexasRECRUITING

San Antonio, Texas
Site Public Contact, 210-575-6240, Vinod.GidvaniDiaz@hcahealthcare.com

University of Texas Health Science Center at San AntonioRECRUITING

San Antonio, Texas
Site Public Contact, 210-450-3800, phoresearchoffice@uthscsa.edu

Huntsman Cancer Institute/University of UtahRECRUITING

Salt Lake City, Utah
Site Public Contact, 888-424-2100, cancerinfo@hci.utah.edu

Children's Hospital of The King's DaughtersRECRUITING

Norfolk, Virginia
Site Public Contact, 757-668-7243, CCBDCresearch@chkd.org

University of Virginia Cancer CenterRECRUITING

Charlottesville, Virginia
Site Public Contact, 434-243-6303, uvacancertrials@hscmail.mcc.virginia.edu

VCU Massey Comprehensive Cancer CenterRECRUITING

Richmond, Virginia
Site Public Contact, 804-628-6430, CTOclinops@vcu.edu

Fred Hutchinson Cancer CenterRECRUITING

Seattle, Washington
Site Public Contact, 800-804-8824

North Star Lodge Cancer Center at Yakima Valley Memorial HospitalRECRUITING

Yakima, Washington
Site Public Contact, 509-574-3535, Memorial-ClinicalTrials@yvmh.org

University of Washington Medical Center - MontlakeRECRUITING

Seattle, Washington
Site Public Contact, 800-804-8824

Valley Medical CenterRECRUITING

Renton, Washington
Site Public Contact, 425-228-3440, research@valleymed.org

Overlake Medical CenterSUSPENDED

Bellevue, Washington

West Virginia University HealthcareRECRUITING

Morgantown, West Virginia
Site Public Contact, 304-293-7374, cancertrialsinfo@hsc.wvu.edu

Cancer Center of Western WisconsinACTIVE_NOT_RECRUITING

New Richmond, Wisconsin

Gundersen Lutheran Medical CenterACTIVE_NOT_RECRUITING

La Crosse, Wisconsin

ClinicalTrials.gov record


NCT04315324. First posted on 3/19/20

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