A drug, enasidenib, in combination with standard treatment, to treat myelodysplastic syndrome (MDS) with an IDH2 mutation (IDH2+)
PrintClinical Trial Goal
You may be able to join this trial if you:
- Are 18 years old or older
- Have IDH2+ MDS
- Have not been treated with any of the following:
- ASTX727
- Azacitidine
- Decitabine
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Cedazuridine is a drug that blocks CDA in certain cells.
Decitabine is a drug that blocks the growth of cancer cells.
Enasidenib is a small molecule inhibitor that blocks IDH2 in certain cells.
In this trial, you’ll be randomized to 1 of 2 groups. Once you’re randomized, you’ll be told what group you’re in:
- Group 1 – Standard treatment with ASTX727
- Group 2 – ASTX727 plus enasidenib
Randomized means doctors will use a computer to assign you to either group. A computer assigns you by chance, like flipping a coin or drawing a name out of a hat. You, your doctor or the clinical trial doctor won’t have any control over which group you’ll be assigned. This means you won’t be able to choose your group.
You’ll get treatment in cycles that last 1 month. In each cycle, you'll get:
- ASTX727 – A pill that you take by mouth 1 time each day for 5 days
- Enasidenib – Group 2 only - A pill that you take by mouth 1 time each day
You may continue treatment for up to 4 months. You'll have biopsies to see how well the treatment is working. The clinical trial doctors will check your health for up to 5 years.
The Food and Drug Administration (FDA) has approved ASTX727 and enasidenib for the treatment of IDH2+ leukemia. Using them together in this way for the treatment of IDH2+ MDS is new and unproven.
Locations
Alta Bates Summit Medical Center-Herrick CampusRECRUITING
Berkeley, California
Site Public Contact, clinicalresearch@sutterhealth.org
Mills Health CenterRECRUITING
San Mateo, California
Site Public Contact, clinicalresearch@sutterhealth.org
Phoebe Putney Memorial HospitalRECRUITING
Albany, Georgia
Site Public Contact, 229-312-0405, ga_cares@augusta.edu
Kootenai Clinic Cancer Services - Post FallsRECRUITING
Post Falls, Idaho
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Kootenai Clinic Cancer Services - SandpointRECRUITING
Sandpoint, Idaho
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Kootenai Health - Coeur d'AleneRECRUITING
Coeur d'Alene, Idaho
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Saint Alphonsus Cancer Care Center-NampaRECRUITING
Nampa, Idaho
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Saint Luke's Cancer Institute - BoiseRECRUITING
Boise, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org
Saint Luke's Cancer Institute - FruitlandRECRUITING
Fruitland, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org
Saint Luke's Cancer Institute - MeridianRECRUITING
Meridian, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org
Saint Luke's Cancer Institute - NampaRECRUITING
Nampa, Idaho
Site Public Contact, 208-381-2774, eslinget@slhs.org
Cancer Care Center of O'FallonRECRUITING
O'Fallon, Illinois
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Cancer Care Specialists of Illinois - DecaturRECRUITING
Decatur, Illinois
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Carle at The RiverfrontRECRUITING
Danville, Illinois
Site Public Contact, 800-446-5532, Research@Carle.com
Carle Cancer CenterRECRUITING
Urbana, Illinois
Site Public Contact, 800-446-5532, Research@carle.com
Carle Physician Group-Mattoon/CharlestonRECRUITING
Mattoon, Illinois
Site Public Contact, 800-446-5532, Research@carle.com
Crossroads Cancer CenterRECRUITING
Effingham, Illinois
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Decatur Memorial HospitalRECRUITING
Decatur, Illinois
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
HSHS Saint Elizabeth's HospitalRECRUITING
O'Fallon, Illinois
Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
Illinois CancerCare-BloomingtonRECRUITING
Bloomington, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-CantonRECRUITING
Canton, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-CarthageRECRUITING
Carthage, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-DixonRECRUITING
Dixon, Illinois
Site Public Contact, 815-285-7800
Illinois CancerCare-EurekaRECRUITING
Eureka, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-GalesburgRECRUITING
Galesburg, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-Kewanee ClinicRECRUITING
Kewanee, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-MacombRECRUITING
Macomb, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-Ottawa ClinicRECRUITING
Ottawa, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-PekinRECRUITING
Pekin, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-PeoriaRECRUITING
Peoria, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-PeruRECRUITING
Peru, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare-PrincetonRECRUITING
Princeton, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Illinois CancerCare - WashingtonRECRUITING
Washington, Illinois
Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com
Loyola University Medical CenterRECRUITING
Maywood, Illinois
Site Public Contact, 708-226-4357
NorthShore University HealthSystem-Evanston HospitalRECRUITING
Evanston, Illinois
Site Public Contact, 847-570-2109
NorthShore University HealthSystem-Glenbrook HospitalRECRUITING
Glenview, Illinois
Site Public Contact, 847-570-2109
NorthShore University HealthSystem-Highland Park HospitalRECRUITING
Highland Park, Illinois
Site Public Contact, 847-570-2109
Northwestern Medicine Cancer Center DelnorRECRUITING
Geneva, Illinois
Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
Northwestern Medicine Cancer Center KishwaukeeRECRUITING
DeKalb, Illinois
Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
Northwestern Medicine Cancer Center WarrenvilleRECRUITING
Warrenville, Illinois
Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
Northwestern Medicine Glenview Outpatient CenterRECRUITING
Glenview, Illinois
Site Public Contact, 312-695-1102
Northwestern Medicine Grayslake Outpatient CenterRECRUITING
Grayslake, Illinois
Site Public Contact, 312-695-1102
Northwestern Medicine Lake Forest HospitalRECRUITING
Lake Forest, Illinois
Site Public Contact, cancertrials@northwestern.edu
Northwestern Medicine Orland ParkRECRUITING
Orland Park, Illinois
Site Public Contact, nctnprogram_rhlccc@northwestern.edu
Northwestern UniversityRECRUITING
Chicago, Illinois
Site Public Contact, 312-695-1301, cancer@northwestern.edu
Southern Illinois University School of MedicineRECRUITING
Springfield, Illinois
Site Public Contact, 217-545-7929
Springfield ClinicRECRUITING
Springfield, Illinois
Site Public Contact, 800-444-7541
Springfield Memorial HospitalRECRUITING
Springfield, Illinois
Site Public Contact, 217-528-7541, pallante.beth@mhsil.com
Swedish Covenant HospitalRECRUITING
Chicago, Illinois
Site Public Contact, 773-878-8200
UC Comprehensive Cancer Center at Silver CrossRECRUITING
New Lenox, Illinois
Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu
University of Chicago Comprehensive Cancer CenterRECRUITING
Chicago, Illinois
Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu
University of Chicago Medicine-Orland ParkRECRUITING
Orland Park, Illinois
Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu
UChicago Medicine Northwest IndianaRECRUITING
Crown Point, Indiana
Site Public Contact, 855-702-8222, cancerclinicaltrials@bsd.uchicago.edu
Mercy Medical Center - Des MoinesRECRUITING
Des Moines, Iowa
Site Public Contact, 515-358-6613, cancerresearch@mercydesmoines.org
The James Graham Brown Cancer Center at University of LouisvilleRECRUITING
Louisville, Kentucky
Site Public Contact, 502-562-3429
UofL Health Medical Center NortheastRECRUITING
Louisville, Kentucky
Site Public Contact, 502-852-2755, ctoinfo@louisville.edu
Our Lady of The LakeRECRUITING
Baton Rouge, Louisiana
Site Public Contact, 225-765-7659
Our Lady of the Lake Physician GroupRECRUITING
Baton Rouge, Louisiana
Site Public Contact, 225-765-7659, research@ololrmc.com
LSU Health Baton Rouge-North ClinicSUSPENDED
Baton Rouge, Louisiana
Tufts Medical CenterRECRUITING
Boston, Massachusetts
Site Public Contact, 617-636-5000, ContactUsCancerCenter@TuftsMedicalCenter.org
Cancer Hematology Centers - FlintRECRUITING
Flint, Michigan
Site Public Contact, 810-762-8038, wstrong@ghci.org
Genesys Hurley Cancer InstituteRECRUITING
Flint, Michigan
Site Public Contact, 810-762-8038, wstrong@ghci.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusRECRUITING
Ypsilanti, Michigan
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - BrightonRECRUITING
Brighton, Michigan
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - CantonRECRUITING
Canton, Michigan
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalRECRUITING
Chelsea, Michigan
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia HospitalRECRUITING
Livonia, Michigan
Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
Genesee Hematology Oncology PCSUSPENDED
Flint, Michigan
Essentia Health Cancer CenterRECRUITING
Duluth, Minnesota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Essentia Health - Deer River ClinicRECRUITING
Deer River, Minnesota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Essentia Health Hibbing ClinicRECRUITING
Hibbing, Minnesota
Site Public Contact, 218-786-3308
Essentia Health Saint Joseph's Medical CenterRECRUITING
Brainerd, Minnesota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Essentia Health SandstoneRECRUITING
Sandstone, Minnesota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Essentia Health Virginia ClinicRECRUITING
Virginia, Minnesota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Hennepin County Medical CenterRECRUITING
Minneapolis, Minnesota
Site Public Contact, 952-993-1517, mmcorc@healthpartners.com
BJC Outpatient Center at Sunset HillsRECRUITING
Sunset Hills, Missouri
Site Public Contact, 314-996-5569
Missouri Baptist Medical CenterRECRUITING
St Louis, Missouri
Site Public Contact, 314-996-5569
Missouri Baptist Sullivan HospitalRECRUITING
Sullivan, Missouri
Site Public Contact, 314-996-5569
Parkland Health Center - FarmingtonRECRUITING
Farmington, Missouri
Site Public Contact, 314-996-5569
Sainte Genevieve County Memorial HospitalRECRUITING
Sainte Genevieve, Missouri
Site Public Contact, 314-996-5569
Benefis Sletten Cancer InstituteRECRUITING
Great Falls, Montana
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Billings Clinic Cancer CenterRECRUITING
Billings, Montana
Site Public Contact, 800-996-2663, research@billingsclinic.org
Bozeman Health Deaconess HospitalRECRUITING
Bozeman, Montana
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Community Hospital of AnacondaRECRUITING
Anaconda, Montana
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Community Medical CenterRECRUITING
Missoula, Montana
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Logan Health Medical CenterRECRUITING
Kalispell, Montana
Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
Community Medical CenterRECRUITING
Toms River, New Jersey
Site Public Contact, 732-557-8294, Lennette.Gonzales@rwjbh.org
Monmouth Medical CenterRECRUITING
Long Branch, New Jersey
Site Public Contact, 732-923-6564, mary.danish@rwjbh.org
Rutgers Cancer Institute of New JerseyRECRUITING
New Brunswick, New Jersey
Site Public Contact, 732-235-7356
University of New Mexico Cancer CenterRECRUITING
Albuquerque, New Mexico
Site Public Contact, 505-925-0348, HSC-ClinicalTrialInfo@salud.unm.edu
Roswell Park Cancer InstituteRECRUITING
Buffalo, New York
Site Public Contact, 800-767-9355, askroswell@roswellpark.org
Duke University Medical CenterRECRUITING
Durham, North Carolina
Site Public Contact, 888-275-3853
Essentia Health Cancer Center-South University ClinicRECRUITING
Fargo, North Dakota
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Ohio State University Comprehensive Cancer CenterRECRUITING
Columbus, Ohio
Site Public Contact, 800-293-5066, Jamesline@osumc.edu
University of Oklahoma Health Sciences CenterRECRUITING
Oklahoma City, Oklahoma
Site Public Contact, 405-271-8777, ou-clinical-trials@ouhsc.edu
Geisinger Medical CenterRECRUITING
Danville, Pennsylvania
Site Public Contact, 570-271-5251, HemonCCTrials@geisinger.edu
University of Pittsburgh Cancer Institute (UPCI)RECRUITING
Pittsburgh, Pennsylvania
Site Public Contact, 412-647-8073
Prisma Health Cancer Institute - ButternutRECRUITING
Greenville, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - EasleyRECRUITING
Easley, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - EastsideRECRUITING
Greenville, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - FarisRECRUITING
Greenville, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - GreerRECRUITING
Greer, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - SenecaRECRUITING
Seneca, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Prisma Health Cancer Institute - SpartanburgRECRUITING
Boiling Springs, South Carolina
Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org
Huntsman Cancer Institute/University of UtahRECRUITING
Salt Lake City, Utah
Site Public Contact, 888-424-2100, cancerinfo@hci.utah.edu
VCU Massey Comprehensive Cancer CenterRECRUITING
Richmond, Virginia
Site Public Contact, 804-628-6430, CTOclinops@vcu.edu
Swedish Cancer Institute-EdmondsRECRUITING
Edmonds, Washington
Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org
Swedish Cancer Institute-IssaquahRECRUITING
Issaquah, Washington
Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org
Swedish Medical Center-First HillRECRUITING
Seattle, Washington
Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org
Duluth Clinic AshlandRECRUITING
Ashland, Wisconsin
Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org
Gundersen Lutheran Medical CenterRECRUITING
La Crosse, Wisconsin
Site Public Contact, 608-775-2385, cancerctr@gundersenhealth.org
Marshfield Medical Center-River Region at Stevens PointRECRUITING
Stevens Point, Wisconsin
Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center - WestonRECRUITING
Weston, Wisconsin
Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org
Medical College of WisconsinRECRUITING
Milwaukee, Wisconsin
Site Public Contact, 414-805-3666
Saint Vincent Hospital Cancer Center at Saint Mary'sRECRUITING
Green Bay, Wisconsin
Site Public Contact, 920-433-8889, wi_research_admin@hshs.org
Saint Vincent Hospital Cancer Center Green BayRECRUITING
Green Bay, Wisconsin
Site Public Contact, 920-433-8889, WI_research_admin@hshs.org
William S Middleton VA Medical CenterRECRUITING
Madison, Wisconsin
Site Public Contact, 608-256-1901
Sponsors
lead: National Cancer Institute (NCI)
