Clinical Trial Goal
To find out:
- The highest dose of tulmimetostat that's safe to give
- If tulmimetostat is safe and works well to treat mycosis fungoides or Sezary syndrome
You may be able to join this trial if you:
- Are 18 years old or older
- Have mycosis fungoides or Sezary syndrome
- Do not have lymphoma in your brain or spinal cord
- Have not been treated with an EZH2 inhibitor. Your doctor can tell you this
- Have not had an allogeneic (cells from a donor) blood or marrow transplant (BMT) in the last 3 months
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Tulmimetostat is a small molecule inhibitor that blocks EZH2/EZH1 in certain cells.
You’ll get treatment in cycles that last 1 month. In each cycle, you'll get:
You’ll get treatment in cycles that last 1 month. In each cycle, you'll get:
- Tulmimetostat – A pill that you take by mouth 1 time each day
You may continue treatment for about 1 year. You'll have scans to see how well the treatment is working. The clinical trial doctors will check your health for up to 3 years.
The Food and Drug Administration (FDA) has not yet approved tulmimetostat.
Locations
Washington University School of MedicineRECRUITING
St Louis, Missouri
Neha Mehta-Shah, M.D., 314-747-7510, mehta-n@wustl.edu
Sponsors
collaborator: Novartis, collaborator: The Foundation for Barnes-Jewish Hospital, collaborator: Swim Across America, collaborator: Daniel E. Corbin Jr. Lymphoma Fund, lead: Washington University School of Medicine
