Clinical Trial Goal
To find out:
- The highest dose of TAA CTLs that is safe to give
- If TAA CTLs are safe and work well to treat multiple myeloma
You may be able to join this trial if you:
- Are 18 years old or older
- Have one of the following:
- Multiple myeloma
- Monoclonal gammopathy of undetermined significance (MGUS) that doctors consider high risk
- Smoldering myeloma that doctors consider high risk
- Agree to have other standard tests done to see if you can be in the clinical trial
Trial Details
Cytotoxic T lymphocytes are made in a lab from your own T cells, which are a kind of immune cell.
You’ll have apheresis, a process to collect, separate and save your T cells. The clinical trial doctors will treat your cells in a lab to make CTLs that target myeloma cells.
Next, the TAA CTLs are given back to you through an intravenous (IV) infusion. The dose you'll get depends on when you start the trial. You'll get 2 infusions of cells, given 2 weeks apart. Each infusion takes about 10 minutes. If the doctors think it's best for your health, you might get up to 6 more infusions of TAA CTLs, given 1 month apart.
You'll have scans and bone marrow biopsies to see how well the treatment is working. After you finish treatment, the clinical trial doctors will check your health for up to 4 years.
The Food and Drug Administration (FDA) has not yet approved TAA CTLs to treat multiple myeloma.
You’ll have apheresis, a process to collect, separate and save your T cells. The clinical trial doctors will treat your cells in a lab to make CTLs that target myeloma cells.
Next, the TAA CTLs are given back to you through an intravenous (IV) infusion. The dose you'll get depends on when you start the trial. You'll get 2 infusions of cells, given 2 weeks apart. Each infusion takes about 10 minutes. If the doctors think it's best for your health, you might get up to 6 more infusions of TAA CTLs, given 1 month apart.
You'll have scans and bone marrow biopsies to see how well the treatment is working. After you finish treatment, the clinical trial doctors will check your health for up to 4 years.
The Food and Drug Administration (FDA) has not yet approved TAA CTLs to treat multiple myeloma.
Contacts
Premal Lulla, MD, 832-824-4847, lulla@bcm.edu
Wendy Callejas, 832-824-1538, wlcalle2@texaschildrens.org
Locations
Harris Health Ben Taub HospitalRECRUITING
Houston, Texas
Martha Mims, MD, 713-798-7535, mmims@bcm.edu
Harris Health Smith ClinicRECRUITING
Houston, Texas
Martha Mims, MD, 713-798-7535, mmims@bcm.edu
Houston Methodist HospitalRECRUITING
Houston, Texas
Contacts:
- Premal Lulla, MD, 832-824-4847, lulla@bcm.edu
- Wendy Callejas, 832-824-1538, wlcalle2@texaschildrens.org
Sponsors
collaborator: The Methodist Hospital Research Institute, collaborator: Center for Cell and Gene Therapy, Baylor College of Medicine, collaborator: Harris County Hospital District, lead: Baylor College of Medicine
