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CAR T-cell therapies treat some types of lymphoma and leukemia

Number of ParticipantsN/A
Research GoalImprove Survival
Chimeric antigen receptor T-cells, or CAR T-cells, are a new type of cellular therapy. 

The American Society for Transplantation and Cellular Therapy (ASTCT) updated its guidelines about BMT to include CAR T-cell therapy. 

BMT has been used for more than 50 years 

BMT can cure leukemia, lymphoma, multiple myeloma, sickle cell disease and some rare diseases. 

Because BMT can have serious side effects, it is not used for everyone. However, newer treatments that are given before BMT, called reduced-intensity conditioning, cause fewer side effects than older treatments. 

So doctors now suggest BMT for more people than before. Even older adults can get life-saving BMT, as long as they are healthy enough. 

CAR T-cell therapy uses modified blood cells to kill cancer cells 

CAR T-cell therapy uses a person’s own T cells, a type of blood cell, that have been altered to kill cancer cells. 

In the U.S. as of January 2021, CAR T-cells are used only after regular treatments fail to control these cancers: 
  • mantle cell lymphoma, 
  • diffuse large B-cell lymphoma, 
  • and acute lymphoblastic leukemia (ALL). 

Scientists are working to create CAR T-cell therapies for more diseases. 

Clinical trials can help 

Experts say people (and their doctors) should join a clinical trial about BMT or CAR T-cells when possible. That way, researchers can learn more about which treatments work best, which helps everyone. 

Keep in mind 

Ask your doctor about the best treatment for you.