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Medicines keep away both GVHD and cancer

Age18 - 75 years old
Number of Participants273
Research GoalImprove Survival
Blood and marrow transplants can cure blood cancers such as leukemias, lymphomas and myelodysplasia. However, after transplant, about half of people get GVHD. In GVHD, the cells from your donor (the graft) attack your own body’s cells (the host). In some cases, GVHD can be life-threatening. 

Scientists wanted to know which medicines can be given before and after transplant to prevent GVHD while keeping cancer away, helping people live longer and feel better. 

They tested 3 different combinations of medicines. One combination worked best—people who took it lived longer without either GVHD or the cancer coming back. It included 3 medicines given after transplant: tacrolimus, mycophenolate mofetil and cyclophosphamide

About 500 adults from around the U.S. volunteered to join this study. Almost half of the people received standard care, and the other half were randomly assigned to 1 of the 3 medicine combos. Another study is planned to compare the best combo with standard care. 

Consider asking your doctor 

What are the best medicines for me to prevent GVHD