Although BMT can cure these problems, it also can cause GVHD. In GVHD, the donated cells may attack the skin and organs. Prednisone is a medicine that treats GVHD, but side effects may include infections and high blood sugar.
In the study, scientists compared two groups of people after about a month of treatment.
- The first group got sirolimus only (with the goal to avoid steroid treatment)
- The second group got standard high doses of prednisone only (no sirolimus)
Both groups had equal rates of control of GVHD. But the people who got sirolimus did better than the prednisone-only group in some ways. They were more likely to:
- stop immune suppression medicines
- have normal blood sugar
- have fewer infections
- have better quality of life