New treatment for GVHD has fewer side effects
Sirolimus treats graft-versus-host disease
Age0 - 74 years old
Number of Participants127
Research GoalImprove Survival
Scientists studied 127 people with GVHD during 2016-2018. The people had had a blood or marrow transplant (BMT) in the United States for leukemia, lymphoma or other disorders.
Although BMT can cure these problems, it also can cause GVHD. In GVHD, the donated cells may attack the skin and organs. Prednisone is a medicine that treats GVHD, but side effects may include infections and high blood sugar.
In the study, scientists compared two groups of people after about a month of treatment.
Although BMT can cure these problems, it also can cause GVHD. In GVHD, the donated cells may attack the skin and organs. Prednisone is a medicine that treats GVHD, but side effects may include infections and high blood sugar.
In the study, scientists compared two groups of people after about a month of treatment.
- The first group got sirolimus only (with the goal to avoid steroid treatment)
- The second group got standard high doses of prednisone only (no sirolimus)
Both groups had equal rates of control of GVHD. But the people who got sirolimus did better than the prednisone-only group in some ways. They were more likely to:
- stop immune suppression medicines
- have normal blood sugar
- have fewer infections
- have better quality of life
Keep in mind
This was a small study of mostly adults with lower risk acute GVHD. More research is needed. Ask your doctor about the best GVHD treatment for you, personally.