Scientists studied 27,000 people who got BMT during 1988 to 2016 in North America or Japan. Everyone got BMT from a donor who was not related to them.
People’s survival after transplant was linked to both their race and their genes. The researchers looked specifically at human leukocyte antigen (HLA) genes.
Previous studies have shown that BMT works best when:
- Donor and patient have fully matched HLA genes
- Patient has TT leader HLA-B genes
- Patient has FEY-negative HLA-DRB1 genes
These ideal circumstances were most common for Japanese patients. They lived longer than White American patients. In turn, White American patients lived longer than Black and African American patients.
Keep in mind
This study did find that Black and African American patients now live longer after BMT than they did years ago.